1997
DOI: 10.1001/archderm.133.2.189
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P53 oncoprotein expression and gene mutations in some keratoacanthomas

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Cited by 11 publications
(16 citation statements)
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“…Ha synergism with PTEN in KA versus previous SCC aetiology (Yao et al, 2006), and the relative lack of typical initiating c-ras Ha or p53 mutations (Ahmed et al, 1997;Lieu et al, 1991;Perez et al, 1997;Ren et al, 1996), these murine data suggest a separate molecular aetiology. However, this idea, again, awaits analysis of whether additional/appropriate mutations of c-ras…”
Section: Hk1fos/δ5ptenmentioning
confidence: 76%
See 1 more Smart Citation
“…Ha synergism with PTEN in KA versus previous SCC aetiology (Yao et al, 2006), and the relative lack of typical initiating c-ras Ha or p53 mutations (Ahmed et al, 1997;Lieu et al, 1991;Perez et al, 1997;Ren et al, 1996), these murine data suggest a separate molecular aetiology. However, this idea, again, awaits analysis of whether additional/appropriate mutations of c-ras…”
Section: Hk1fos/δ5ptenmentioning
confidence: 76%
“…However, whether Fos/Pten null synergism drives human KA aetiology remains to be confirmed, although roles for Fos in hyperproliferative disease and keratinocyte differentiation/turnover (Angel et al, 2001;Mehic et al, 2005) and the hyperkeratosis following PTEN loss (Fistarol et al, 2002;Stambolic et al, 2000;Yao et al, 2006) would be consistent with the increased differentiation in KAs. In addition, most human KAs are devoid of p53 mutations and exhibit increased p21 WAF expression (Ahmed et al, 1997;Perez et al, 1997;Ren et al, 1996). These data fuel the debate on whether KA represents a differentiated extreme of SCC or a class of benign tumour in their own right, with a separate molecular aetiology.…”
Section: Hk1fos/δ5ptenmentioning
confidence: 96%
“…Mutation studies of p53 gene confirm a higher incidence of mutations in squamous cell carcinoma, in contrast to keratoacanthoma. 25,26 They found no correlation between immunohistochemical detection of p53 oncoprotein and gene mutations, and recommend sequence analysis to determine gene mutation. From the above studies, it appears that although immunohistochemical determination is helpful, sequence analysis of p53 gene is essential to identify the mutation.…”
Section: Discussionmentioning
confidence: 99%
“…7,8 Mutation studies of the p53 gene confirm a higher incidence of mutations in squamous cell carcinoma, in contrast to keratoacanthoma. 25,26 Materials and methods A total of 17 cases of well to moderately differentiated cutaneous squamous cell carcinoma and 24 early phase keratoacanthoma were retrieved from the files of National University Hospital Pathology Department. Poorly differentiated squamous cell carcinomas were excluded from the study, as they posed little diagnostic problems in distinguishing from keratoacanthoma.…”
mentioning
confidence: 99%
“…19 The mutations in p53 are the most frequently found gene in cutaneous SCCs 20, 53, 54 but appear not to be common in keratoacanthomas. 55 In addition, several studies have suggested that mutant p53 can act in cooperation with v-Ha-ras to inhibit negative growth regulation by TGF-␣. 56,57 Therefore, interesting results may be obtained by analysis of p53 status in the rabbits with keratoacanthomas and SCCs.…”
Section: Discussionmentioning
confidence: 99%