2021
DOI: 10.2147/ndt.s273578 View full text |Buy / Rent full text
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Abstract: Purpose Glioblastoma multiforme (GBM) is an aggressive brain tumor with a rather short survival time. Mutation of p53 has been observed and reported to play critical roles in the progression of GBM. However, the pathological mechanisms are still unclear. This study was designed to identify the role of miR-154 in mediating the biological functions of p53 in glioblastoma multiforme. Methods In the current study, the expression of miR-154 in GBM tissue samples and cell lin… Show more

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“…This interaction also provides a new field of vision for the treatment of GBM ( 43 ). TCF12 has been proved to be an important target for miR-154 and can regulate the epithelial-mesenchymal transformation of GBM ( 44 ). P53/miR-154/TCF12 pathway may be involved in inhibiting the growth and invasion of GBM cells, so it can be used as a potential therapeutic target ( 44 ).…”
Section: Discussionmentioning
“…TCF12 has been proved to be an important target for miR-154 and can regulate the epithelial-mesenchymal transformation of GBM (44). P53/miR-154/TCF12 pathway may be involved in inhibiting the growth and invasion of GBM cells, so it can be used as a potential therapeutic target (44). Another marker gene, RGS14, is highly expressed in the caudate nucleus of the brain and thymus (45)(46)(47).…”
Section: Discussionmentioning