P53 gene: major mutations in neoplasias and anticancer gene therapy

Lima, Caroline de Oliveira Escola de Veterinária e Zootecnia ) Rocha; Rabelo, Rogério Elias; Vulcani, Valcinir Aloísio Scalla; Cardoso, Lorena Damasio; Sousa, Nicaelle Luan de Moura; Moura, Veridiana Maria Brianezi Dignani de

doi:10.1590/s0103-84782012000500014

Cited by 5 publications

(2 citation statements)

References 41 publications

(45 reference statements)

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“…This regulates the cell cycle checkpoints, so that DNA damage is repaired (81). The p53 gene is important in cell carcinogenesis, senescence, apoptosis and gene repair (82). When cells are exposed to external stimuli that induce DNA damage, such as chemotherapy drugs, ionizing radiation, gene mutation or telomerase shorting, the p53 gene is activated (83).…”

Section: Senescence Induction Pathwaysmentioning

confidence: 99%

Possibility of inducing tumor cell senescence during therapy (Review)

et al. 2021

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Section: Senescence Induction Pathwaysmentioning

confidence: 99%

Possibility of inducing tumor cell senescence during therapy (Review)

et al. 2021

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“…TP53 is an essential protein which functions as 'tumour suppressor' in multicellular organisms. It is denoted as p53 or TP53 gene and is located on the short arm of chromosome 17 encodes TP53 protein whose chief function is to prevent genomic mutations while conserving the stability of the genome 3 . Most of the mutations hinder the ability of TP53 to bind to the target DNA, further on blocking the transcriptional activation, indicating a 'recessive loss of function mutation'.…”

Section: Tumour Protein Tp53 and Cancermentioning

confidence: 99%

Expressions of biomarkers in MCF7 Breast and Colon Cancer Cell Lines

Rao¹,

Deeba²

2020

J. Drug Delivery Ther.

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Cancer is one of the leading causes of death which accounts for 13% of total deaths, worldwide. Colorectal and Breast cancer fall under main categories according to World Health Organisation (WHO) cancer facts sheet 1. The need to understand the expression of clinical biomarkers in breast cancer and colon cancer is necessary for diagnosis and therapeutic response. In this article, the expressions of histone H1 and TP53 biomarkers were established for four different colon cancer cell lines and compared with the expressions of MCF7 cell line. The results show varied expression of Histone H1 along with TP53 markers among the cell lines. The results suggest that the linker Histone H1 has shown nuclear localization in HCT 116p53 wt (wild type) cancer cell line whereas it has shown cytoplasmic distribution in the respective null type cell line with intense expression. The result also suggests that a localized distribution in HRA19 cells and a diffused distribution in SNU-C2B cell line. These established results were compared with the expression of the biomarkers in MCF7 in order to get a better understanding. Keywords: Tumour Proteins, p53, H1, MCF-7 cell, HCT116, HRA19.

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