p53 and Vascular Dysfunction: MicroRNA in Endothelial Cells

Abstract

In many cancer cells, p53 gene is mutated and accumulated, which is considered as a mechanistical target of tumorigenesis. The role of p53 in non-cancerous cells has been focused on, since p53 activation diversely affects as human diseases, including vascular dysfunctions. p53 regulates vascular events, including vascular inflammation and senescence as well as cardiac dysfunction. Many researchers also have paid attention to the role of noncoding RNAs (ncRNAs), especially small-sized microRNAs (miRNAs) for the last decade and their noble biological cellular functions have been discovered. miRNAs expressed in endothelial cells (endothelial miRNAs) have been shown to control vascular events. Firstly, the importance of p53 in a variety of vascular events, such as vascular inflammation and senescence, are summarized. Secondly, the way to regulate miRNAs by p53 and the involvement of miRNAs on p53 function are demonstrated. Finally, several endothelial miRNAs that have important roles are focused on. The aim of this chapter is to understand the role of p53 in vascular diseases in the view of endothelial cell biology and the contribution of miRNAs related to p53.

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

“…This MC is located at 5q33.1, encodes for miR-143 and miR-145, and is widely studied for its function in vascular biology and pathology related to cardiovascular disease. 101 Members of this MC are reported to regulate genes associated with cell propagation, cell cycle progression, migration, invasion and apoptosis in several cancer types. 102 miR-145 and miR-143 are downregulated in OC tissue samples and cell lines.…”

Cysteine Glutathionylation Acts as a Redox Switch in Endothelial Cells

“…p53 is gatekeeper of a wide range of cellular pathways, mostly known for its antitumorigenic properties preventing abnormal cells proliferating. However, the role of p53 in non-cancerous cells such as ECs has recently attracted interest due to its crucial implications in angiogenesis, apoptosis and vascular dysfunction [101]. p53 S-glutathionylation inhibition of DNA binding and protein dimerization has been reported in cancerous cells [22], having potential implications in EC function and vascular pathologies associated with defects in angiogenesis regulation.…”