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Cited by 6 publications
(3 citation statements)
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References 8 publications
(16 reference statements)
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“…Other authors demonstrated that p53 transcriptional response to oxidative stress also depends on p66Shc (Migliaccio et al 2013). In fact, p66Shc knockout mice have increased resistance to oxidative stress (Gambino et al 2013).…”
Section: Discussionmentioning
confidence: 98%
“…Other authors demonstrated that p53 transcriptional response to oxidative stress also depends on p66Shc (Migliaccio et al 2013). In fact, p66Shc knockout mice have increased resistance to oxidative stress (Gambino et al 2013).…”
Section: Discussionmentioning
confidence: 98%
“…The gene SHC1 is located on chromosome 1 and encodes 3 main protein isoforms: p66Shc, p52Shc and p46Shc and differ in molecular weight. p66Shc, a 66 kDa proto-oncogene Src collagen homologue (Shc) adaptor protein is a longevity protein and has many effects involved with cell receptor tyrosine kinase signal transduction, nutrient metabolism and increased levels of p66Shc (Ser phosphorylation) have been shown to block mitosis, inhibit glucose metabolism and associated with the regulation of reactive oxygen species induced cell apoptosis [54]- [57]. p66Shc antagonizes insulin and mTOR effects which limits glucose uptake and inhibits anabolic metabolism [58] [59].…”
Section: P66shcmentioning
confidence: 99%
“…In conditions with increased ROS generation, including cardiac ischemia, the cytochrome c binding domain in p66 Shc binds with cytochrome c leading to electrons transferring from cytochrome c to oxygen to increase ROS generation [ 101 ]. Downregulation of p66 Shc leads to decreased ROS generation and prolonged mouse life span, indicating that ROS generation from p66 Shc contributes to the aging process [ 103 , 104 ].…”
Section: Oxidant Stress and Cardiovascular Diseasementioning
confidence: 99%