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Cited by 125 publications
(162 citation statements)
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References 56 publications
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“…The mechanisms through which Mediator might act to facilitate pol IIG function are not known, but it is relevant that TFIIF serves to specifically align pol II with Mediator (35,36). This effect of TFIIF depends on the interaction of an activator with Mediator (35), consistent with the earlier observation that activators can drive structural changes in Mediator (37). Thus, Mediator may facilitate the otherwise weak ability of TFIIF to support PIC assembly despite the presence of Gdown1.…”
Section: Discussionsupporting
confidence: 73%
“…The mechanisms through which Mediator might act to facilitate pol IIG function are not known, but it is relevant that TFIIF serves to specifically align pol II with Mediator (35,36). This effect of TFIIF depends on the interaction of an activator with Mediator (35), consistent with the earlier observation that activators can drive structural changes in Mediator (37). Thus, Mediator may facilitate the otherwise weak ability of TFIIF to support PIC assembly despite the presence of Gdown1.…”
Section: Discussionsupporting
confidence: 73%
“…In addition, all the 40 predicted Med26 subunits showed the Pfam Med26 domain having the conserved TFIIS helical bundle domain, a conserved N-terminal region found in the transcription elongation factors TFIIS and Elongin A (Booth et al, 2000). Although the role of Med26 in plants remains to be established, it appears that Med26 may play a role in transcription elongation, as has been reported for the Cdk8 submodule in the serum response network (Donner et al, 2010) and in p53-directed Pol II elongation via the Med complex in humans (Meyer et al, 2010). For each core module of the Med (head, middle, and tail), a high conservation except for one or two subunits was observed across kingdoms.…”
Section: Evidence Of Animal Med26 In Plantsmentioning
confidence: 88%
“…The Med complex has the flexibility to acquire different structures upon binding of different activators to different/same subunits (Taatjes et al, 2002(Taatjes et al, , 2004. These distinct activator-Med structures differentially affect Pol II activity (Meyer et al, 2010) and regulate Med function in genespecific ways . Although the function of Med as a GTF has been widely accepted (Takagi and Kornberg, 2006), its role as a global regulator of transcription has been questioned in some recent reports (Deato et al, 2008;Thiaville et al, 2008).…”
mentioning
confidence: 99%
“…The functional bivalency of CDK8 is quite enigmatic, but structural studies may provide a clue. Mediators exhibit a structural change when they bind various types of transcriptional activators (60) and therefore exist as multiple structurally distinct subcomplexes. Some of these subcomplexes may bind tightly to PRMT5 and act as corepressors, as described in this paper, whereas others may lack PRMT5 and act as coactivators.…”
Section: Dissociation Of Mediator Cdks From C/ebp␤ Target Genes Changmentioning
confidence: 99%