2011
DOI: 10.1111/j.1369-1600.2010.00302.x View full text |Buy / Rent full text
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Abstract: P50 gating is a major functional biomarker in research on schizophrenia and other psychiatric conditions with high smoking prevalence. It is used as endophenotype for studying nicotinic systems genetics and as surrogate endpoint measure for drug development of nicotinic agonists. Surprisingly, little is known about P50 gating in the general population and the relationship to smoking-related characteristics. In this multicenter study at six academic institutions throughout Germany, n=907 never-smokers (NS<20 ci… Show more

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“…Finally, the covariate age (P = 4.1 × 10 −14 to 7.7 × 10 −15 , η p 2 = 0.033-0.035) revealed a significant effect, whereas the impact of sex, study center, cotinine plasma level, and longitude/latitude of study center was not significant (all tests: F < 1.25). As shown before (53), sensory gating increases with age (see also correlation analyses in SI Discussion). Longitude and latitude were included in the analysis to control for subtle population differences between the sampling sites.…”
Section: Resultssupporting
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“…Finally, the covariate age (P = 4.1 × 10 −14 to 7.7 × 10 −15 , η p 2 = 0.033-0.035) revealed a significant effect, whereas the impact of sex, study center, cotinine plasma level, and longitude/latitude of study center was not significant (all tests: F < 1.25). As shown before (53), sensory gating increases with age (see also correlation analyses in SI Discussion). Longitude and latitude were included in the analysis to control for subtle population differences between the sampling sites.…”
Section: Resultssupporting
“…The study was carried out in the framework of the German multicenter study: Nicotine: Physiological and Molecular Effect in the CNS (53,79). All subjects were randomly selected from the local general population of seven cities across Germany (Aachen, Berlin, Bonn, Düsseldorf, Erlangen, Mainz, and Mannheim) via official residents' registers and contacted by letter with an invitation to participate in the study.…”
Section: Methodsmentioning
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“…The P50 response was the most positive peak between 48 and 68 m s after stimulus onset (both after S1 and S2) (Nagamoto et al, 1991). The P50 amplitude was measured relative to the preceding negativity and the amplitude difference scores (S1 e S2) were calculated (for details see Brinkmeyer et al, 2011). A low value of the difference indicates weak inhibition of the second tone (i.e., no gating or filtering) or low P50 amplitude after the first tone.…”
Section: Neurophysiological Measurements and Analysesmentioning
“…The SOP, staff training and comparability of data collection and data quality across centers was established within the framework of a previous study (Mobascher et al, 2010;Brinkmeyer et al, 2011). At all four study sites, EEG data were recorded using a 32-channel EEG system from Brain Products, Gilching, Germany (BrainAmp DC Ò ).…”
Section: Neurophysiological Measurements and Analysesmentioning