2015
DOI: 10.1074/jbc.m114.633461
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Abstract: Background: How reduced ROS signaling regulates inflammation and remodeling in bone remains unknown. Results: Age-related switch of bone mass in p47 phox -deficient mice occurs through an increased inflammatory milieu in bone. Conclusion: p47phox -Nox2-dependent physiological ROS signaling suppresses inflammation in aging. Significance: p47phox -Nox2 and Nox4 may play different roles during early development and skeletal involution because they serve unique functions on osteoblast differentiation and prolifera… Show more

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Cited by 26 publications
(23 citation statements)
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“…NADPH oxidase is one of the main sources of ROS production, and p47 phox is an important subunit of NADPH oxidase (Rastogi, Geng, Li & Ding, 2016). A previous study showed knockout of p47 phox decreased over 50% of ROS production in p47 phox −/− mice compared with the wild‐type mice, which indicated that decrease in physiological ROS level would cause a negative effect to bone metabolism, and finally resulted in bone loss (Chen et al., 2015). It was well demonstrated that AOPPs could induce ROS generation via the activation of NADPH oxidase.…”
Section: Discussionmentioning
confidence: 99%
“…NADPH oxidase is one of the main sources of ROS production, and p47 phox is an important subunit of NADPH oxidase (Rastogi, Geng, Li & Ding, 2016). A previous study showed knockout of p47 phox decreased over 50% of ROS production in p47 phox −/− mice compared with the wild‐type mice, which indicated that decrease in physiological ROS level would cause a negative effect to bone metabolism, and finally resulted in bone loss (Chen et al., 2015). It was well demonstrated that AOPPs could induce ROS generation via the activation of NADPH oxidase.…”
Section: Discussionmentioning
confidence: 99%
“…In mice, loss of NADPH oxidase activity accelerated aging (Chen et al, 2015; Lee et al., 2011). By contrast, chronic ROS generation by NADPH oxidase has been suggested to promote age-dependent diseases (Krause, 2007), showing that NADPH oxidase and the generated ROS need to be tightly regulated.…”
Section: Discussionmentioning
confidence: 99%
“…Aged mice globally deficient in p47 phox , a subunit of the NOX2 enzyme, have decreased bone mass and strength due to deficits in osteoblast differentiation, osteoblast number, and accelerated cell senescence (60). This phenotype is not observed in 6-week-old mice, which have increased bone mass.…”
Section: Discussionmentioning
confidence: 99%