P450 fatty acid decarboxylase

Jiang, Yuanyuan; Li, Shengying

doi:10.1016/bs.mie.2023.09.004

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2024

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“…Numerous reviews have been published to cover the diverse mechanisms of decarboxylation. , There are also reviews that focus on specific subsets of decarboxylases based on their cofactors, such as TPP-dependent decarboxylases, , PLP-dependent decarboxylases, , P450 fatty acid decarboxylases, and prFMN-dependent decarboxylases . Additionally, there are reviews that delve into the specific mechanisms of decarboxylation, including oxidative and nonoxidative decarboxylation …”

Section: Introductionmentioning

confidence: 99%

Decarboxylation in Natural Products Biosynthesis

Nguyen,

Forstater,

McIntosh

2024

JACS Au

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Decarboxylation reactions are frequently found in the biosynthesis of primary and secondary metabolites. Decarboxylase enzymes responsible for these transformations operate via diverse mechanisms and act on a large variety of substrates, making them appealing in terms of biotechnological applications. This Perspective focuses on the occurrence of decarboxylation reactions in natural product biosynthesis and provides a perspective on their applications in biocatalysis for fine chemicals and pharmaceuticals.

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