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Cited by 3 publications
(10 citation statements)
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References 7 publications
(10 reference statements)
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“…Interestingly, we detected increased p-p38 levels in freshly isolated neutrophils of both MDS-EB-II patients compared with a healthy control (Fig. 5D), pointing to a preactivation of p38 in the course of MDS, which is corroborated by literature addressing the role of p38 in MDS (26). Because we detected a correlation between the highest migration speed and low p-p38 levels in healthy individuals (Fig.…”
Section: Mds Type and Ipss-r Scoring Correlate With The Neutrophil MIsupporting
confidence: 84%
See 1 more Smart Citation
“…Interestingly, we detected increased p-p38 levels in freshly isolated neutrophils of both MDS-EB-II patients compared with a healthy control (Fig. 5D), pointing to a preactivation of p38 in the course of MDS, which is corroborated by literature addressing the role of p38 in MDS (26). Because we detected a correlation between the highest migration speed and low p-p38 levels in healthy individuals (Fig.…”
Section: Mds Type and Ipss-r Scoring Correlate With The Neutrophil MIsupporting
confidence: 84%
“…Recently, MAPK p38 emerged as a target of MDS therapy. Various reports suggest that p38 dysregulation drives alterations of immune responses and inflammatory signals during MDS progression (23)(24)(25)(26). Thus, p38 inhibitors like ARRY-614, a p38/Tie2 dual inhibitor, are in clinical trials (27).…”
mentioning
confidence: 99%
“…The inhibition of p38 MAPK could additionally result in several pleiotropic effects that could be beneficial in inhibition of myelodysplastic syndrome progression and improving hematopoiesis in these patients. 57 However, how much of this latter effect depends on upregulation of HO-1 requires further study. Nevertheless, as reported here, inhibition of p38 MAPK, which leads to upregulation of HO-1, resulted in decreased migration of HSPCs in response to C3a, C5a and SDF-1 gradients.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, some small molecules that upregulate expression of HO-1 and inhibit p38 MAPK could also potentially find practical application, and our in vivo results lend support to this possibility. Of note, inhibition of p38 MAPK has already been employed in the clinic to inhibit progression of myelodysplastic syndrome (MDS) and to improve hematopoiesis in MDS patients (50).…”
Section: Introductionmentioning
confidence: 99%