p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

Sui, Xinbing; Kong, Na; Li, Ye; Han, Weidong; Zhou, Jichun; Zhang, Qin; He, Chao; Pan, Hongming

doi:10.1016/j.canlet.2013.11.019

Cited by 813 publications

(602 citation statements)

References 92 publications

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“…Cleaved caspase‐3, caspase‐6, and, caspase‐7 protein levels were also decreased in Cheongja#3‐pretreated cells prior to exposure of H 2 O 2 (Figure 3b). Since the MAPK pathway is the main signaling source for inducing apoptosis (Sui et al., 2014), we tested phosphorylated p38, phosphorylated extracellular‐signal‐regulated kinase (ERK) 1/2, phosphorylated c‐jun N‐terminal kinase (JNK) protein levels. Cheongja#3 extract downregulated H 2 O 2 ‐induced phosphorylated p38 and JNK protein expression, whereas phosphorylated ERK 1/2 protein levels were not affected by Cheongja#3 extracts (Figure 3c).…”

Section: Resultsmentioning

confidence: 99%

“…We have detected cleaved caspase‐3, caspase‐6, and, caspase‐7 in the H 2 O 2 ‐treated cells, but found antiapoptotic effects of Cheongja#3 by the rescued cleaved caspases. Mitogen‐activated protein kinase pathway, especially phosphorylated p38 and JNK, is en route to apoptosis in response to environmental stress such as ROS (Chen, Liu, Yin, Luo, & Huang, 2009; Sui et al., 2014). Phosphorylated JNK and phosphorylated p38 protein expressions were increased upon treatment of H 2 O 2 as other studies have shown.…”

Section: Discussionmentioning

confidence: 99%

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Black soybeans protect human keratinocytes from oxidative stress‐induced cell death

Yoon

Lee

Song

et al. 2018

Food Science & Nutrition

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Black soybeans are functional foods containing a variety of bioactives such as isoflavones, carotenoids, tocopherols, phenolic acid as well as anthocyanins. Here, we examined whether Cheongja#3 black soybean extract has a protective effect on oxidative stress‐induced cell death in human keratinocytes HaCaT. First, we identified fat‐soluble bioactives in three varieties of soybean extracts (Saedanbaek, Daechan, and Cheongja#3). In particular, black soybean Cheongja#3 had high amounts of lutein than other varieties. We demonstrated that Cheongja#3 extract reduced intracellular reactive oxygen species levels in HaCaT cells. Furthermore, Cheongja#3 protected cells from hydrogen peroxide (H2O2)‐induced oxidative stress and triggered cell death determined by cell viabilities and apoptotic caspase activities. Next, we identified the underlying mechanism is due to increased Nrf2 antioxidant system by Cheongja#3, thus increasing the expression of heme oxygenases (HO)‐1. These results indicated that Cheongja#3 soybean extract has protective role against oxidative stress by upregulating the Nrf‐2 antioxidant system in human keratinocyte HaCaT cells.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Black soybeans protect human keratinocytes from oxidative stress‐induced cell death

Yoon

Lee

Song

et al. 2018

Food Science & Nutrition

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“…The role of stress-activated MAPKs such as p38 and JNK in cancer cells outcome seems to vary in a tumor-dependent manner, but their modulation may be implicated in response to anticancer drugs. 32,33 It has been reported that in HCT-116 CRC cell line, p38 MAPK plays an important role in oxaliplatin-induced apoptosis. 34 Here we found that the combination of sub-micromolar doses of PBOX-15 (300 nM) and Oxaliplatin cooperates to induce apoptosis possibly through activation of p38 and JNK MAPKs, as evidenced by the cleavage of caspase 3.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

Fiore

Proto

Pisanti

et al. 2015

Cancer Biology & Therapy

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Some compounds of a series of novel pyrrolo-1,5-benzoxa(thia)zepine, a well-known group of tubulin targeting agents, display anti-tumor effects mainly inducing cell cycle arrest and apoptosis in several human cancer models. A member of this family, pyrrolo-1,5-benzoxazepine-15 (PBOX-15), has previously shown potent pro-apoptotic activity in a variety of human tumor cell types, with minimal toxicity toward normal blood and bone marrow cells. In this study, we evaluated the PBOX-15-mediated effects in human colorectal cancer cell (CRC) lines, DLD-1 and HT-29. The compound, used at concentrations equal to or greater than 1 mM, inhibited the proliferation of human CRC cells, inducing a significant cell cycle arrest in the G2/M phase. In DLD-1 cells, treatments prolonged over 48 h triggered a strong activation of the intrinsic apoptotic pathway as indicated by activation of caspase-9, caspase-3 and PARP cleavage. Moreover, nanomolar concentrations of PBOX-15, significantly improved the oxaliplatin and 5-fluouracilinduced anti-proliferative effects in DLD1 cell line. The observed synergistic interaction of both PBOX-15/ Oxaliplatin and PBOX-15/5FU may involve activation of p38 MAPK and JNK pathway, which in turn significantly increased caspase-3 cleavage in DLD-1 cells, treated with PBOX-5/Oxaliplatin but not with PBOX-15/5FU. Moreover, PBOX-15/5FU-treated cells showed an increase in expression of the proapoptotic protein Bax. Taken together, these results show that PBOX-15 could represent a promising compound for the treatment of human CRC and a strong candidate for novel therapeutic options.

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“…Our results indicated that neurotropin prevented oxaliplatin-induced neurotoxicity and cell death in cultured DRG neurons. MAPK signaling plays an important role in the sensitivity to anticancer drugs [24]. Activated MAPK transmits extracellular signals to regulate many cellular processes such as cell proliferation, migration, differentiation [25], and apoptosis [26].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Neuroprotective Effects of Neurotropin in Cultured Rat Dorsal Root Ganglion Neurons Using High- Throughput Imaging

Akita¹,

Sato²,

Yoshida³

et al. 2017

J Biomedical Sci

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Background: Neurotropin, a non-protein extract derived from inflamed rabbit skin following inoculation with vaccinia virus, is an analgesic agent. The mechanism of action of neurotropin has been partially clarified. No experimental study, however, has been undertaken to assess oxaliplatin-induced neurotoxicity using quantitative in vitro high-throughput image analysis. In the present study, to elucidate the action of neurotropin on dorsal root ganglion (DRG) neurons, we explored the antioxidative and anti-inflammatory activity of neurotropin. We assessed the viability and morphological changes in cultured rat DRG neurons treated with oxaliplatin and neurotropin.

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p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

Cited by 813 publications

References 92 publications

Black soybeans protect human keratinocytes from oxidative stress‐induced cell death

Black soybeans protect human keratinocytes from oxidative stress‐induced cell death

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

Assessment of Neuroprotective Effects of Neurotropin in Cultured Rat Dorsal Root Ganglion Neurons Using High- Throughput Imaging

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