P350 Atherosclerotic and Metabolic Repercussions of Increased Plasma Levels of Oxidized LDL and Antibodies Against Oxidized LDL in Asymptomatic Adults

Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

“…Furthermore, ox-LDL was positively associated with other lipid biomarkers, such as total cholesterol and LDL-c, in accordance to previous studies [ 7 , 8 , 16 , 41 , 42 ]. Interestingly, the participants of this study are young adults predominantly normolipidemic (total cholesterol <200 mg/dL and LDL-c <160 mg/dL represent 92.5 and 97.5% of the sample, respectively).…”

“…Regarding the association of ox-LDL concentrations with anthropometric and body fat distribution data, BMI was significantly higher in those individuals with high ox-LDL, while truncal was significantly positively associated with ox-LDL concentrations. However, both variables were not able to predict to ox-LDL concentrations, which is not in agreement with other studies [ 6 - 8 ]. In fact, the body fat distribution, characterized by central fat accumulation, has been associated with increasing in pro-inflammatory and oxidative stress markers [ 6 , 23 , 45 ].…”

“…However, both variables were not able to predict to ox-LDL concentrations, which is not in agreement with other studies [6-8]. In fact, the body fat distribution, characterized by central fat accumulation, has been associated with increasing in pro-inflammatory and oxidative stress markers [6,23,45].…”

“…In this sense, oxidized low-density lipoproteins (ox-LDL), a recognized oxidative stress marker, has been positively associated with central obesity [ 6 ], metabolic syndrome manifestation [ 7 ] and atherosclerosis [ 8 ]. Also, uric acid has been proposed as independent risk factor for cardiovascular diseases [ 9 , 10 ], in addition to implication in LDL-c oxidation and generation of an oxidative status in hyperuricemia conditions [ 11 , 12 ].…”