p300 KAT regulates SOX10 stability and function in human melanoma
Aaron Waddell,
Nicole Grbic,
Kassidy Leibowitz
et al.
Abstract:SOX10 is a lineage-specific transcription factor critical for melanoma tumor growth, while SOX10 loss-of-function drives the emergence of therapy-resistant, invasive melanoma phenotypes. A major challenge has been developing therapeutic strategies targeting SOX10’s role in melanoma proliferation, while preventing a concomitant increase in tumor cell invasion. Here, we report that the lysine acetyltransferase (KAT)EP300andSOX10gene loci on Chromosome 22 are frequently co-amplified in melanomas, including UV-ass… Show more
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