P3‐216: Plasma acetylcholinesterase activity is correlated with intracerebral beta‐amyloid load measured <i>in vivo</i>

Alkalay, Adi; Rabinovici, Gil D.; Zimmerman, Gabriel; Agarwal, Neha; Kaufer, Daniela; Miller, Bruce L.; Jagust, William W.; Soreq, Hermona

doi:10.1016/j.jalz.2010.05.1715

Cited by 2 publications

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“…При этом в ткани мозга изменяется соотношение активности АХЭ и БХЭ [32,33]. Также показано наличие прямой корреляции между уров-нем активности АХЭ в плазме крови и числом амилоид-ных депозитов в мозге при БА [34]. Предварительные дан-ные указывают на изменение активности этих ферментов при нарушении когнитивных функций и у животных [35].…”

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The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

Журавин

Nalivaeva

Козлова

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

Журавин

Nalivaeva

Козлова

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Valproic acid potentiates curcumin-mediated neuroprotection in lipopolysaccharide induced rats

Zaky

Mahmoud

Awad

et al. 2014

Front. Cell. Neurosci.

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The etiology of neuroinflammation is complex and comprises multifactorial, involving both genetic and environmental factors during which diverse genetic and epigenetic modulations are implicated. Curcumin (Cur) and valproic acid (VPA), histone deacetylase 1 inhibitor, have neuroprotective effects. The present study was designed with an aim to investigate the ability of co-treatment of both compounds (Cur or VPA, 200 mg/kg) for 4 weeks to augment neuroprotection and enhance brain recovery from intra-peritoneal injection of (250 μg/kg) lipopolysaccharide-stimulated neuroinflammatory condition on rat brain cortex. Cortex activation and the effects of combined treatment and production of proinflammatory mediators, cyclooxygenase-2 (COX-2), APE1, and nitric oxide/inducible nitric oxide synthase (iNOS) were investigated. Neuroinflammation development was assessed by histological analyses and by investigating associated indices [β-secretase (BACE1), amyloid protein precursor (APP), presenilin (PSEN-1), and PSEN-2)]. Furthermore we measured the expression profile of lethal-7 (let-7) miRNAs members a, b, c, e, and f in all groups, a highly abundant regulator of gene expression in the CNS. Protein and mRNA levels of neuroinflammation markers COX-2, BACE1, APP, and iNOS were also attenuated by combined therapy. On the other hand, assessment of the indicated five let-7 members, showed distinct expression profile pattern in the different groups. Let-7 a, b, and c disappeared in the induced group, an effect that was partially suppressed by co-addition of either Cur or VPA. These data suggest that the combined treatment induced significantly the expression of the five members when compared to rats treated with Cur or VPA only as well as to self-recovery group, which indicates a possible benefit from the synergistic effect of Cur-VPA combination as therapeutic agents for neuroinflammation and its associated disorders. The mechanism elucidated here highlights the particular drug-induced expression profile of let-7 family as new targets for future pharmacological development.

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P3‐216: Plasma acetylcholinesterase activity is correlated with intracerebral beta‐amyloid load measured in vivo

Cited by 2 publications

References 0 publications

The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease

Valproic acid potentiates curcumin-mediated neuroprotection in lipopolysaccharide induced rats

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