volume 93, issue 0, P3-P-276 2020
DOI: 10.1254/jpssuppl.93.0_3-p-276
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Abstract: Microglia are professional phagocytes which play an important role in homeostasis maintenance in the central nervous system. These cells rapidly detect and remove apoptotic cells which expose phosphatidylserine (PtdSer) as the key "eat-me" signal on the cell surface. This process is largely mediated through TAM receptor tyrosine kinases, MER and AXL, and TAM ligands which are soluble bridging proteins binding to PtdSer. We have previously reported that LPSstimulated microglia promoted dying cell phagocytosis v…

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