P269 The first case-control study comparing diagnostic outcomes in irritable bowel syndrome and self-reported gluten sensitivity

Abstract

had had a dietetic review suggestive of good GFD adherence. RCD1 patients with ongoing VA (n=44) were invited to complete three gluten immunogenic peptides (GIP) tests, using rapid immunochromatographic testing, following the collection of mid-stream urine samples. Ongoing gluten ingestion was defined as having at least one weak positive/positive urine GIP sample. Results At diagnosis, RCD 1 patients were significantly younger than RCD2/CCD patients (p=0.002). 38 RCD1 patients with ongoing VA were recruited (71.1% female [n=27], median age 60 years). 52.6% (n=20) of patients with RCD1 had three negative GIP tests, suggestive of strict GFD adherence. However, 47.4% (n=18) had at least one positive GIP result, suggestive of possible ongoing gluten exposure.Conclusions A high proportion of individuals with RCD1 appear to have ongoing gluten exposure despite reported strict GFD adherence, as assessed by urine GIP. Urine GIP may redefine and enable the accurate diagnosis of RCD1 in the future.