volume 2, issue 8, PS551 2007
DOI: 10.1097/01.jto.0000283616.67499.dc
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Abstract: Object: Discuss the change of the EGFR expression and downstream signal pathway in A549 cell treated with ZD1839. Methods: The inhibition of the A549 cell treated with ZD1839 was measured by MTT assay and Real-Time PCR was used to evaluate the expression of EGFR and downstream signal pathway. Results: A549 cell was inhibited by ZD1839 in vitro. After treated with ZD1839, the expression of EGFR was 1.10 fold compared with the cell without ZD1839 and Ras gene was 1.09 fold. The expression of MAPK was 52.1 percen…

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