volume 2, issue 8, PS541 2007
DOI: 10.1097/01.jto.0000283591.09867.2a
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Abstract: found in the amplified cell lines. This amplification confers sensitivity of NSCLC to inhibitors of the tyrosine kinase activity of c-Met. To further determine the molecular characteristics of cell lines carrying c-Met amplification, we investigated the levels of downstream effectors of c-Met, such as phospho paxillin, phospho-extracellular signalregulated kinase and phospho-S6 proteins. Interestingly, S6 kinase a serine-threonine kinase whose activation is thought to regulate a wide array of cellular processe…

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