volume 2, issue 8, PS496 2007
DOI: 10.1097/01.jto.0000283477.92464.9f
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Abstract: Background: The Nm23-H1 gene is a metastasis suppressor gene. However, its biochemical mechanism of suppressing the met static potential of cancer cells is still unknown. The previous hypothesis that a histidine protein kinase activity may contributes to the motility-suppressive effect of Nm23-H1 could not explain why the H118F mutant, a kinase-deficient mutant, still had motility-suppressive ability. Methods: We conducted a study on the double mutant P96S/S120G of Nm223-H1 and succeeded in introducing the RP-…

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