volume 2, issue 8, PS484 2007
DOI: 10.1097/01.jto.0000283448.70819.aa
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Abstract: The homeobox containing gene LAGY (Lung Cancer Associated Gene Y Genbank accession Nr. AF454763), also named Hop (Homeodomain only protein), was identified in the developing heart and lung where it functions downstream of Nkx2.5 and Nkx2.1 to modulate cardiac and lung gene expression. Previously, we found that LAGY was downregulated in lung cancer cell lines and primary lung tumors and the downregulation was linked to higher tumor grading. In this study, we constructed an expression vector containing the fulll…

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