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Cited by 9 publications
(4 citation statements)
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References 9 publications
(14 reference statements)
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“…However, a highly pronounced inhibitory effect was observed in ANM-treated cells. Immunoblotting showed that ANA, ANH and ANM significantly down-regulated the HG-induced increase in p16 INK4A , a tumor suppressor protein known to transduce senescence-signals and lead to irreversible growth arrest [ 33 ]. In addition, ANA, ANH and ANM significantly inhibited HG-induced p21 CIP1 expression, a cyclin-dependent kinase inhibitor that regulates growth-arrest and cellular senescence [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, a highly pronounced inhibitory effect was observed in ANM-treated cells. Immunoblotting showed that ANA, ANH and ANM significantly down-regulated the HG-induced increase in p16 INK4A , a tumor suppressor protein known to transduce senescence-signals and lead to irreversible growth arrest [ 33 ]. In addition, ANA, ANH and ANM significantly inhibited HG-induced p21 CIP1 expression, a cyclin-dependent kinase inhibitor that regulates growth-arrest and cellular senescence [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this case, the individual role of a particular tumor suppressor varies depending on the genetic and environmental circumstances, and inactivation of just one of the tumor suppressors may be insufficient to fully induce the state of oncogene tolerance (discussed by Gil and Peters 37 ). Interestingly, akin to other ETS family members, 38 ETV1 has been identified recently as a possible regulator of the p16-specific promoter in the INK4A locus. 39 Together with the data presented here, this suggests that the activity of ETV1 is also under intense scrutiny of tumor suppressors.…”
Section: Discussionmentioning
confidence: 99%
“…При этом индукция p16 совпадала с увеличением активности SA-b-gal [7]. Считается, что р53 и p21 CIP1/WAF1 играют важную роль в инициации клеточного старения, а р16 INK4a передаёт сигналы, приводящие к необратимой остановке пролиферации [14].…”
Section: культура клетокunclassified