P1‐177: Telephone Administration of the Cdr: Excellent Agreement With Face‐to‐face Administration

Randolph, Christopher; Williams, Janet B. W.; Hannesdóttir, Kristín; Eureyecko, Elizabeth; Langbaum, Jessica B.; Tariot, Pierre N.; Farlow, Martin R.; Galvin, James E.; Langlois, Carolyn; Hunt, Cynthia; Olsson, Tina M.; Poole, Michael D.; Weber, Christopher J.; Boehm, Peter; Cohen, Elan D.; Garzio, Lori M.; Alexander, Robert S.

doi:10.1016/j.jalz.2014.05.415

Cited by 2 publications

(2 citation statements)

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“…Sites are encouraged to contact all participantsduring study shutdown to reassure them that the MarkVCID studies remain active and will resume when fully safe. Sites are permitted to perform telephone assessment of clinical elements not affected by remote administration such as participant demographics, medical and family history, CDR Scale, and Geriatric Depression Score44,45 for the purposes of shortening the duration of face-to-face clinical assessments or when scheduled clinical visits are delayed by study site shutdown. We also promote flexibility with neuropsychological assessment, offering modifications, guidance, and training for telephone or video-based assessments.…”

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confidence: 99%

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols

Wilcock

Jicha

Blacker

et al. 2021

Alzheimer's & Dementia

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The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple contributing pathologies and (2) along with the preeminent role of Alzheimer's disease (AD) pathology, cerebrovascular disease accounts for a substantial proportion of this contribution. Contributing cerebrovascular processes include both overt strokes caused by etiologies such as large vessel occlusion, cardioembolism, and embolic infarcts of unknown source, and frequently asymptomatic brain injuries caused by diseases of the small cerebral vessels. Cerebral small vessel diseases such as arteriolosclerosis and cerebral amyloid angiopathy, when present at moderate or greater pathologic severity, are independently associated with worse cognitive performance and greater likelihood of dementia, particularly in combination with AD and other neurodegenerative pathologies. Based on this evidence, the US National Alzheimer's Project Act explicitly authorized accelerated research in vascular and mixed dementia along with frontotemporal and Lewy body dementia and AD itself. Biomarker development has been consistently identified as a key step toward translating scientific advances in VCID into effective prevention and treatment strategies. Validated biomarkers can serve a range of purposes in trials of candidate interventions, including (1) identifying individuals at increased VCID risk, (2) diagnosing the presence of cerebral small vessel disease or specific small vessel pathologies, (3) stratifying study participants according to their prognosis for VCID progression or treatment response, (4) demonstrating an intervention's target engagement or pharmacodynamic mechanism of action, and (5) monitoring disease progression during treatment. Effective biomarkers allow academic and industry investigators to advance promising interventions at early stages of development and discard interventions with low success likelihood. The MarkVCID consortium was formed in 2016 with the goal of developing and validating fluid‐ and imaging‐based biomarkers for the cerebral small vessel diseases associated with VCID. MarkVCID consists of seven project sites and a central coordinating center, working with the National Institute of Neurologic Diseases and Stroke and National Institute on Aging under cooperative agreements. Through an internal selection process, MarkVCID has identified a panel of 11 candidate biomarker “kits” (consisting of the biomarker measure and the clinical and cognitive data used to validate it) and established a range of harmonized procedures and protocols for participant enrollment, clinical and cognitive evaluation, collection and handling of fluid samples, acquisition of neuroimaging studies, and biomarker validation. The overarching goal of these protocols is to generate rigorous validating data that could be used by investigators throughout the research community in selecting...

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confidence: 99%

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols

Wilcock

Jicha

Blacker

et al. 2021

Alzheimer's & Dementia

View full text Add to dashboard Cite

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“…Previous studies of remote administration of cognitive assessments have reported good correlations with results from F2F administration, though with potential variability according to age and type of assessment. [5][6][7] After the successful set-up and implementation of the virtual visits, we plan to compare results of all assessments obtained through the remote visits with those obtained at last prelockdown physical visit and the first post-lockdown (typically within a 3-month period). By evaluating which elements of the assessments retain validity under remote conditions and which are compromised, we hope to report findings to inform the choice of assessments in future studies.…”

Section: Implications For Wider Research and Future Considerationsmentioning

confidence: 99%

Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid‐19 pandemic. Operationalizing adaptive methods and challenges

Udeh-Momoh

Jager-Loots

Price

et al. 2020

A&D Transl Res & Clin Interv

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The COVID‐19 pandemic necessitated adaptations to standard operations and management of clinical studies, after lockdown measures put in place by several governments to reduce the spread of SARS‐COV‐2. In this paper, we describe our telehealth strategy developed for transitioning our dementia prevention clinical observational prospective study from face‐to‐face visits to virtual visits, to ensure the ongoing collection of longitudinal data. We share the lessons learned in terms of challenges experienced and solutions implemented to achieve successful administration of study assessments. Our methods will be useful for informing longitudinal observational or interventional studies that require a feasible model for remote data collection, in cognitively unimpaired adults.

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P1‐177: Telephone Administration of the Cdr: Excellent Agreement With Face‐to‐face Administration

Cited by 2 publications

References 0 publications

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols

Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid‐19 pandemic. Operationalizing adaptive methods and challenges

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