P049 Skeletal muscle involvement in COVID-19 infection: a case report and systematic review

Abstract

Background/Aims It is increasingly understood that COVID-19 has a very broad range of multi-system manifestations. Myalgia is a widely publicised feature of SARS-CoV-2 infection, however, more severe muscle injury can occur. There are several case reports of rhabdomyolysis with marked elevation in creatine kinase (CK) and myoglobinuria, leading to acute renal failure, but also reports of myositis characterised by weakness, mildly raised CK and muscle oedema on MRI. We present a systematic literature search to evaluate the clinical characteristics of skeletal muscle involvement. Methods A systematic search for terms related to "SARS-CoV-2" and "myalgia", "myositis", "rhabdomyolysis" or "muscle" was performed across four search engines (Web of Science, Pubmed, Mednar and Medrxiv) on 10/09/2020. Only original research published or translated in English was included. Information relating to skeletal muscle injury in confirmed SARS-CoV-2 infection was summarised. Results The search protocol identified 980 articles of which 200 were appropriate for abstract review. 21 case reports covering 22 patients with rhabdomyolysis were found. Other muscular pathology not defined as rhabdomyolysis by authors, included 1 case of acute myositis leading to compartment syndrome, 2 cases of myositis with classical proximal weakness, elevated creatine kinase and proximal muscle oedema on imaging, and one series of 7 patients with paraspinal myositis on MRI imaging. A histopathological study found evidence of incidental myositis in 2 cases. Critical care myopathy and polyneuropathy are described, along with many other neurological manifestations. While 91 cohort studies were identified, none looked in detail at skeletal muscle involvement. There are 8 meta-analyses which find the prevalence of myalgia between 19-33%. The age of rhabdomyolysis patients appears lower than expected for covid-19 admissions at 46.7 years, but ranged from 16 to 88. Baseline characteristics mirror those at higher risk of severe covid-19: half had either hypertension, type 2 diabetes or obesity and 86.4% were male. Common accompanying symptoms were myalgia (81.8%), fever (68.2%), cough (59.1%), dyspnoea (40.9%). Median peak CK was 22,511IU/L. 68.2% had changes consistent with covid-19 on chest imaging. Intravenous haemofiltration or mechanical ventilation were each required by 4 patients. Short term prognosis showed 18 (81.8%) being discharged, 2 deaths (9.1%) and 2 unknown outcomes. Conclusion Severe skeletal manifestations such rhabdomyolysis occur in covid-19. More research is needed to discover if this is through direct viral invasion of the tissues, or indirectly via systemic cytokine release, hyperlactataemia and hypo-oxygenation. CK should be routinely checked in those critically unwell or with severe myalgia or weakness to identify treatable rhabdomyolysis early. Chronic autoimmune conditions such as the idiopathic inflammatory myopathies may have viral environmental triggers, and one case tested positive for a myositis specific antibody. Whether patients with acute covid-19 related myositis experience ongoing long-term muscle inflammation has not yet been reported. Disclosure J.R. Hannah: None. S. Ali: None. J. Galloway: None. P. Gordon: None.

COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

“…Results with nuclear imaging of patients with severe CK elevation shows that the myositis associated with the infection is diffuse and not localized to one area of the body [92]. Thus far, there has not been evidence suggesting direct infection of muscle tissue with SARS-CoV-2 and no single cytokine pathway has been associated with the inflammation [93]. Only one autopsy study of patients that died during the acute infection detected SARS-CoV-2 RNA in some muscle tissue, but did not observe virus present by immunohistochemistry or electron microscopy [94].…”