P039 - Faecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse

Gisbert, J.P.; Bermejo, Fernando; Pérez-Calle, J.L.; Taxonera, Carlos; Vera, Isabel; McNicholl, Adrián G.; Algaba, Alicia; Lopez, P; López-Palacios, Natalia; Calvo, M. Espinosa; González-Lama, Yago; Carneros, J.A.; Velasco, Marta; Maté, J.

doi:10.1016/s1873-9946(09)60066-0

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15,38 Recently, some authors have determined the role of fecal lactoferrin in the prediction of IBD, both in patients with UC and CD, in a large, long-term follow-up study. 70 One hundred sixty-three IBD pa-tients who had been in clinical remission for 6 months were included, and provided a single stool sample for lactoferrin determination at baseline. During the 12-month follow-up period, 10% of the patients with a negative fecal lactoferrin test relapsed, while this occurred in 25% of those having a positive test.…”

Section: Is Fecal Lactoferrin Determination Useful To Predict the Relmentioning

confidence: 99%

“…Therefore, the authors conclude that fecal lactoferrin determination may be useful in predicting impending clinical relapse-especially during the following 3 months-in both CD and UC patients. 70 In another study, fecal specimens were collected from 148 consecutive pediatric patients with CD or UC. 38 Patients who experienced a clinical flare within 2 months of specimen collection displayed higher lactoferrin levels than did those who remained in clinical remission.…”

Section: Is Fecal Lactoferrin Determination Useful To Predict the Relmentioning

confidence: 99%

See 1 more Smart Citation

Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease

Gisbert

McNicholl

Gomollón

2009

Inflammatory Bowel Diseases

113

View full text Add to dashboard Cite

Among the available fecal biomarkers for the diagnosis and monitoring of inflammatory bowel disease (IBD), only calprotectin and lactoferrin have translated into useful clinical tools. Lactoferrin can be detected using simple and cheap techniques and it has excellent stability in feces over a long period of time. Fecal lactoferrin has a good diagnostic precision for separating organic and functional intestinal disease. However, a negative fecal lactoferrin test should be interpreted merely as the absence of significant neutrophilic intestinal inflammation. The mean sensitivity and specificity of the fecal lactoferrin determination for the diagnosis of IBD is 80% and 82%, respectively. Some studies have suggested a lower accuracy of lactoferrin when compared with calprotectin for the diagnosis of IBD, indicating that more studies on this topic are necessary. A parallel between fecal lactoferrin levels and IBD activity estimated with clinical, endoscopic, and histological parameters has been confirmed. However, this correlation seems to be lower in Crohn's disease than in ulcerative colitis, mainly when Crohn's disease patients with purely ileal disease are considered. Fecal lactoferrin determination may be useful in predicting impending clinical relapse in IBD patients. Fecal lactoferrin may be a helpful noninvasive diagnostic tool for monitoring therapeutic efficacy, mainly on mucosal healing, as a decreasing concentration of lactoferrin can be interpreted as a marker of therapeutic response. Finally, in patients with Crohn's disease who have undergone ileocolonic resection, those with higher lactoferrin fecal levels might be more prone to postsurgical recurrence.

show abstract

Section: Is Fecal Lactoferrin Determination Useful To Predict the Relmentioning

confidence: 99%

Section: Is Fecal Lactoferrin Determination Useful To Predict the Relmentioning

confidence: 99%

Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease

Gisbert

McNicholl

Gomollón

2009

Inflammatory Bowel Diseases

113

View full text Add to dashboard Cite

show abstract

P039 - Faecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse

Cited by 1 publication

References 0 publications

Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease

Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease

Contact Info

Product

Resources

About