P011 TNF inhibition combined with chemotherapy for experimental tuberculosis improves pulmonary bacterial clearance and reduces pathology

Bourigault, Marie L.; Vacher, Rachel; Rose, Stéphanie; Olleros, Maria L.; Ryffel, Bernhard; Quesniaux, Valérie; García, Irene

doi:10.1016/j.cyto.2012.06.094

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous clinical cases have reported the use of infliximab therapy after ATT, which effectively mitigated PR in CNS-TB [85,190]. Combining etanercept with standard TB treatment in mice resulted in a significantly lower pulmonary bacterial burden and relapse rate than those of the standard TB treatment [139,191]; another study reported similar results [192]. In a phase I study, etanercept showed favorable responses and was safe for TB treatment in HIV-1 positive groups [193].…”

Section: Tnf-α Antagonistsmentioning

confidence: 93%

Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia

Lu¹,

Guo²,

Wei³

2023

Aging and disease

View full text Add to dashboard Cite

Tuberculous meningitis (TBM) is the most severe complication of tuberculosis (TB) and is associated with high rates of disability and mortality. Mycobacterium tuberculosis (M. tb), the infectious agent of TB, disseminates from the respiratory epithelium, breaks through the blood-brain barrier, and establishes a primary infection in the meninges. Microglia are the core of the immune network in the central nervous system (CNS) and interact with glial cells and neurons to fight against harmful pathogens and maintain homeostasis in the brain through pleiotropic functions. However, M. tb directly infects microglia and resides in them as the primary host for bacillus infections. Largely, microglial activation slows disease progression. The non-productive inflammatory response that initiates the secretion of pro-inflammatory cytokines and chemokines may be neurotoxic and aggravate tissue injuries based on damages caused by M. tb. Host-directed therapy (HDT) is an emerging strategy for modulating host immune responses against diverse diseases. Recent studies have shown that HDT can control neuroinflammation in TBM and act as an adjunct therapy to antibiotic treatment. In this review, we discuss the diverse roles of microglia in TBM and potential host-directed TB therapies that target microglia to treat TBM. We also discuss the limitations of applying each HDT and suggest a course of action for the near future.

show abstract

Section: Tnf-α Antagonistsmentioning

confidence: 93%

Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia

Lu¹,

Guo²,

Wei³

2023

Aging and disease

View full text Add to dashboard Cite

show abstract

“…Более того, два рода бактерий Veillonella и Megasphaera встречались в опухолях легкого значительно чаще других [1]. Также показана связь между злокачественными опухолями легкого и Mycobacterium tuberculosis, активность которых стимулирует синтез фактора некроза опухолей, что, в свою очередь, стимулирует онкологические процессы [2]. Современные исследования подтвердили ассоциацию повышенного содержания Haemophilus influenzae, Enterobacter spp.…”

unclassified

Diagnostic and Prognostic Potential of the Resident Non-Small Cell Lung Cancer Microbiome

Ковалева

Kushlinskii

Podlesnaya

et al. 2023

RCLD

View full text Add to dashboard Cite

The data of a comprehensive comparative study of the taxonomic composition of the resident microbiome of tumors from 26 patients with non-small cell lung cancer are presented. Analysis of taxonomic diversity revealed 10 types, 280 genera and 788 species of microorganisms. The analysis of the relative content and prognostic significance was carried out for 62 dominant genera. Differences in the relative abundance of bacteria of the genera Acinetobacter, Halomonas, and Chryseobacterium between tumor and conditionally normal lung tissue were found, but their diagnostic potential was not confirmed. The correlation analysis did not reveal any relationship between the content of various genera of bacteria and the histological type of the tumor, its localization, and the age of the patients. Differences were found in the content of the studied bacteria depending on the stage of the disease, the presence of regional metastases and tumor differentiation. The prognostic significance of bacteria of the genera Variovorax and Pseudoclavibacter in non-small cell lung cancer was established. The results obtained can be used in the development of new effective methods for the diagnosis and prognosis of non-small cell lung cancer.

show abstract

P011 TNF inhibition combined with chemotherapy for experimental tuberculosis improves pulmonary bacterial clearance and reduces pathology

Cited by 2 publications

References 0 publications

Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia

Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia

Diagnostic and Prognostic Potential of the Resident Non-Small Cell Lung Cancer Microbiome

Contact Info

Product

Resources

About