P-239 Phosphorylation status of the retinoblastoma protein inpreneoplastic bronchial epithelium

Bowman, Rayleen V.; Maclachlan, Roderick; Clarke, B.L.; Duhig, Edwina; Davidson, Marson T.; Fong, Ksk

doi:10.1016/s0169-5002(05)80733-0

Cited by 1 publication

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“…24 Bowman et al from Brisbane studied markers of cell cycling that may be involved in dysregulated cell cycling in preneoplastic lesions. 51,52 Additionally, Guillard et al used quantitative pathology as a biomarker for bronchial intraepithelial neoplasia, showing correlation with genetic damage and cellular transformation. 53 Taken together the abstracts presented at IASLC are a tremendous source of data to help unravel the current mystery of natural history of airway CIS.…”

Section: Discussionmentioning

confidence: 99%

In Situ Carcinoma: Early Diagnosis and Treatment

Downie¹,

Cummings²,

Varju³

2007

Clinical Pulmonary Medicine

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Thoracic oncology providers are frequently challenged with management issues of airway carcinoma-in situ (CIS). The diagnosis, progression, and treatment of CIS are demanding more clinical attention and will affect overall outcomes of lung cancer. Progressive change in normal airway mucosa is classified according to pathologic severity: basal cell hyperplasia, metaplasia, dysplasia, and CIS. Time in each phase, reversibility or repair, and progression remains undefined. Once CIS is present, the development of invasive cancer is more likely and reflected in more aggressive treatment recommendations. The current readily available clinical options for diagnosis in these settings are analysis of sputum and direct endoscopic visualization. The most significant advancement in airway assessment since the development of the flexible bronchoscope has been the implementation of autofluorescence (AF) bronchoscopy. The improved ability to diagnose metaplasia, early stage dysplasia, and CIS has resulted in a controversy of how to treat the newly detected precancerous lesions. Surgery remains the treatment of choice; however, direct comparison of photodynamic therapy alone in CIS with other treatment modalities remains undefined. In patients with early superficial squamous cell carcinoma, electrocautery, cryotherapy, and brachytherapy may be an alternative for treatment. Published peer-reviewed literature over the last decade has begun to address key issues regarding airway CIS. Endoscopic diagnosis and treatment has advanced considerably with clinically superior results available in both areas. Screening, diagnosis, prevention, and treatment of CIS have seen advances in the last decade, but the natural history remains to be revealed.T horacic oncology providers, whether in a multidisciplinary setting or as individual clinicians, are frequently challenged with management issues of airway carcinoma-in situ (CIS). The diagnosis, progression, and treatment of CIS, especially in high-risk populations, are demanding more clinical attention to determine surveillance strategies and will affect overall outcomes of lung cancer in the near future.At the recent 11th World Congress on Lung Cancer in Barcelona (International Association for the Study of Lung Cancer; IASLC), most topic sections included several abstracts directly or indirectly discussing research or clinical aspects of CIS. These presentations ranged from the basic science of biomarkers in CIS, to endoscopic detection and surveillance. Other sections had presentations discussing sputum cytology techniques and efficacies, the significance of CIS at surgical resection sites, and newer treatment options, including chemoprevention of CIS.In the clinical setting, discussions of airway CIS usually revolves around 4 basic questions:1. What is the natural history of CIS in the central airway? 2. How much cellular transformation needs to be present to warrant treatment: moderate or severe dysplasia, CIS, or obvious carcinoma? 3. What is the best approach for detection of CIS: routin...

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Section: Discussionmentioning

confidence: 99%