P.13.5 Colorectal Cancer in Patients With Type 2 Diabetes Mellitus: Preliminary Results From an Ongoing Case-Control Study

Sinagra, Emanuele; Raimondo, Domenico; Messina, Maria Francesca; Mocciaro, Filippo; Dolcimascolo, Serena; Rizzolo, A.C.; Puccia, Fania; Maltese, N; Marasà, S; Cottone, Mario; Tomasello, Gianluca; Monte, Attilio Ignazio Lo; Sinagra, D

doi:10.1016/s1590-8658(14)60302-9

Cited by 2 publications

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“…Similarly, several epidemiological studies reported a close association between IR assessed by the homeostasis model assessment method (HOMA-IR) and the risk of colorectal cancer ( 23 , 24 ), as did experimental studies ( 25 , 26 ). A study speculated sulphonylureas may play a role in CRC carcinogenesis impairing the physiological insulin secretion among diabetes participants ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk

Liu

Liang

et al. 2022

Front. Endocrinol.

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BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.

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Section: Discussionmentioning

confidence: 99%

Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk

Liu

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…These results were confirmed in a recently published cohort study by the same author on 169,601 patients using metformin (HR 0.50, 95 % confidence interval (CI): 0.45-0.56). Similarly, Sinagra et al have shown that longer duration of diabetes is associated with higher risk of CRC (p = 0.001) in the cohort of 741 Caucasian patients with type 2 diabetes [48]. In a large population-based study (36,270 patients with diabetes and 145,080 patients without diabetes), Lin et al showed an increased incidence of cancer, especially gastroenterological malignancies (except for esophageal cancer), in patients with diabetes.…”

Section: The Incidence Of Colorectal Cancermentioning

confidence: 89%

“…Four large cohort studies from the Taiwanese population have been published [47][48][49][50]. First, it was reported that patients with diabetes had a significantly higher risk (24 %) of CRC (relative risk (RR) 1.243, 95 % confidence interval (CI) 1.105-1.399, p = 0.0003) and metformin users had a significantly lower risk (RR 0.731, 95 % CI 0.580-0.921, p = 0.0078), particularly when the duration of exposure to metformin was longer than 3 years (RR 1.185, 95 % CI (1.055, 1.330), p = 0.0042).…”

Section: The Incidence Of Colorectal Cancermentioning

confidence: 99%