P-050. Histochemistry and ultrastructure of the endometrium after hormonal stimulation

Dostál, Jiřı́; Oborná, I; Novotný, Radko; Malínský, J; Lichnovský, V; Tálas, M; Kudela, M; Chrastinová, Ľubica

doi:10.1093/humrep/12.suppl_2.143-a

Cited by 1 publication

(2 citation statements)

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“…Such polyspermic fertilizations lead to chromosomal aneuploidy resulting in embryonic loss. Local and systemic presence of endotoxins also induces degeneration, fragmentation and developmental arrest of preimplantation embryos, and is one of the significant causes of reduced reproductive efficiency in most mammals [7]. A large body of in vivo and in vitro evidence suggests that many of the biological effects of LPS are indirectly mediated by the pro-inflammatory cytokines like, IL-1·, IL-1ß, TNF-·, etc.…”

Section: Gram-negative Bacterial Endotoxins (Lps): Effect On Embryonimentioning

confidence: 99%

“…Lipopolysaccharide (LPS) is known to mimic the pathophysiology of gram-negative bacterial infections. Endotoxins derived from gram-negative bacteria have been found to extensively damage preimplantation stage embryos [7]. The presence of endotoxins during IVF of oocytes results in a high rate of polyspermy, decreased embryo cleavage rate and blastocyst formation in human and bovine species [8].…”

Section: Introductionmentioning

confidence: 99%

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Gram-Negative Bacterial Endotoxin- Induced Infertility: A Birds Eye View

Deb

Chatturvedi

Jaiswal

2004

Gynecol Obstet Invest

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Alleviation of infertility on the one hand and development of improved methods of contraception on the other are global concerns to woman’s health. The molecular signals that regulate implantation are of clinical relevance since understanding the nature of these signals may lead to strategies to correct implantation failure and to develop novel contraceptive approaches. The other pressing concern is the poor pregnancy rate resulting from in vitro fertilization (IVF). The pregnancy rate in IVF programs remains about 20–30% in spite of the high rate of successful fertilization. This has led to the proposition that additional uterine factors, critical for the implantation process, must be limiting. Identification of such parameters could help in determining the appropriate physiological state of the uterus for embryo transfer. Several factors are known to have a direct or indirect impact on the ability of the uterus to develop to a functionally receptive state. This would disrupt the normal coordination between embryonic and uterine development even though all molecular players may seem otherwise normal.

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Section: Gram-negative Bacterial Endotoxins (Lps): Effect On Embryonimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%