OZENA: Streptomycin and Nitrofurazone Therapy

Infections caused by Klebsiella ozaenae: a changing disease spectrum

“…Until recently, however, most investigators have noted its isolation only from the upper respiratory tract (2, 3, 7, 9, 11, 13). peatedly isolated the organism in the sputum of patients with chronic bronchitis for as long as 3 years and isolated it from the sputum of five patients with primary pneumonia in whom there was no other apparent pathogen (13). K. ozaenae was isolated most often from sputum in mixed cultures, but in none of our patients was it established as a cause of lower respiratory tract infection.…”

“…ozaenae has been thought to be a possible pathogen exclusively Mi cases of ozena or atrophic rhinitis (12). Ozena is a chronic rhinitis characterized by atrophic changes in the nasal mucosa and turbinates, enlargement of the nasal passages, and a foul-smelling mucopurulent discharge which tends to dry into crusts (3,13). Many theories as to the etiology of ozena have been proposed (including a bacterial cause), but none has been proven (2,3,13).…”

State of the Art Review: Current Status of Topical Nasal Antimicrobial Agents

“…He subsequently treated six more patients with intranasal nitrofurazone with 50% or greater improvement in symptoms in these patients. 45 More recently, Dudley 46 showed nasal symptom improvement in a patient with atrophic rhinitis who was unresponsive to intravenous tobramycin therapy but who responded to intranasal gentamicin ointment and solution at a daily dose of 3.5 mg for 10 days. In the report, the patient's nasal crusting was diminished and the foul nasal odor disappeared after 1 month.…”

The combined use of antibiotic insufflation and vasodilator therapy in ozena

“…Failure to solve the problem thus far has led to the growing opinion that the disease is not due to anyone single cause but very likely is the product of a combination of factors. 2 , 3 In view of this trend, the significant though limited results obtained with recent independently formulated methods of streptomycin 3 -5 and vasodilator 6 -14 therapy suggested a combined approach for clinical investigation. In 1951, I reported 15 a new method for the treatment of ozena by combining the local use of aqueous streptomycin and other antibiotics with vasodilators in oral form.…”