Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat

Véronneau-Longueville, F; Rampin, Olivier; Freund-Mercier, Marie José; Tang, Yi; Calas, A.; Marson, Lesley; McKenna, Kevin E.; Stoeckel, M. E.; Galand, Benoît; Giuliano, François

doi:10.1016/s0306-4522(99)00262-6

Cited by 126 publications

(92 citation statements)

References 42 publications

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“…apomorphine is the release of oxytocin at the parasympathetic level. 20,21 Systemic apomorphine could not generate further pro-erectile effect, as exogenous i.t. oxytocin would already mimic the full activation of the pro-erectile descending pathway usually activated after i.v.…”

Section: Discussionmentioning

confidence: 99%

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Spinal proerectile effect of apomorphine in the anesthetized rat

et al. 2001

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Considering the presence of dopaminergic receptors in the lumbosacral spinal cord, we tested whether apomorphine could exert a proerectile effect by acting at the spinal level. Intracavernous (ICP) and blood pressures (BP) were measured in anesthetized rats. ICP rises were quanti®ed (duration, percentage of ICPmaximumameanBP (ICPmaxaBP 6 100), area under ICP curve (AUCaBP) and sum of AUCaBP after intravenous (i.v.) and intrathecal (i.t.) injections of apomorphine alone or in presence of i.t. oxytocin (10 ng). Both 10 and 30 m mg i.v. apomorphine dosings elicited erectile events evidenced by ICP rises. Upon the 30 m mg i.v. injection, duration of ICP rises were increased from 25 AE 10 to 69 AE 18 s (P`0.001), ICPmaxaBP 6 100 from 21 AE 3 to 50 AE 14% (P 0.001), AUCaBP from 3 AE 1 to 14 AE 6 s (P 0.002) and sum of AUCaBP from 5 AE 7 to 34 AE 35 s (P 0.021). Upon 30 m mg i.t. injections of apomorphine at the lumbosacral level, the number of ICP rises was increased from 0.2 AE 0.4 to 3.0 AE 1.5, ICPmaxaBP 6 100 from 16 AE 9 to 43 AE 12 and sum of AUCaBP from 1 AE 3 to 31 AE 15 s compared to vehicle injection (P`0.05 for all parameters). Injection of 30 m mg i.v. or i.t. apomorphine non-signi®cantly enhanced the number and amplitude of the ICP rises induced by 10 ng i.t. oxytocin. However, the enhancement of the amplitude of the ICP rises elicited by i.t. oxytocin was more pronounced with i.t. apomorphine than with i.v. apomorphine. These results suggest the existence of a spinal site of action for apomorphine which may (1) participate to generation of erection and (2) exerts a facilitator effect on erection of supraspinal origin.

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Section: Discussionmentioning

confidence: 99%

“…injections of oxytocin at the level of the sacral parasympathetic nucleus triggers the occurrence of erectile events and such injections likely mimic the physiological release of oxytocin through the paraventriculospinal pathway. 20,21 We combined i.t. oxytocin delivery with apomorphine treatment.…”

Section: Discussionmentioning

confidence: 99%

Spinal proerectile effect of apomorphine in the anesthetized rat

et al. 2001

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“…Present data also show that the systemic injection of oxytocin to the PO7 neonatal as well as to the adult male rat induces the immediate activation of ejaculatory rhythmic motor patterns, suggesting that the spinal oxytocinergic system is involved in the functioning of the spinal generator for ejaculation. In the adult male rat, it has been demonstrated that the source of oxytocin for the spinal cord is the hypothalamus, 18 and that electrical stimulation of the posterior hypothalamic area produces the release of important amounts of this peptide; 19 however, an endogenous source of oxytocin in the neonatal spinal cord has not been described. Thus, it is necessary to perform specific experiments to further examine the developmental organization and functioning of the spinal oxytocinergic system and its relation to ejaculation across postnatal development.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat

Carro‐Juárez

Rodrı́guez–Manzo

2005

Int J Impot Res

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A spinal pattern generator controls ejaculation in the male rat. In the present study, the hypothesis that the spinal generator for ejaculation was functional at early postnatal stages was evaluated. To this purpose, the expression of the ejaculatory motor pattern and its pharmacological activation in spinally transected neonatal rats from postnatal day 2 to weaning were investigated. Results revealed the presence of the rhythmic ejaculatory motor pattern in neonatal male rats. As in adult sexually experienced animals, the neonatal ejaculatory motor pattern could be elicited after the application of an ejaculation-like-releasing stimulus. The rhythmic genital motor response of neonates exhibited a gradual maturation that was reflected in its motor parameters until showing the features of the adult response at postnatal day 28. Besides, the ejaculatory motor pattern could be induced by the systemic injection of oxytocin in 7-day-old neonates as well as in adult animals. Present findings provide evidence for the presence of the spinal generator for ejaculation early during postnatal development, suggesting that its organisation is innate.

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“…Immunoreactive oxytocin-containing spinal neurons associating with sacral preganglionic neurons con®rmed by retrograde labelling supports the role of oxytocin in the autonomic spinal circuitry that mediates penile erection. 11,25 Central oxytocin seems to be involved in the expression of penile erection induced not only by drugs but also by sexual physiological stimuli, since non-contact erections in rats were reduced dosedependently by a selective oxytocin receptor antagonist, given into the lateral ventricles. 26 The oxytocinergic system may be in¯uenced by the NO synthase signal transduction pathway, since inhibitors of this pathway prevent penile erection and yawning in rats induced by oxytocin, dopamine, and NMDA stimulation.…”

Section: Oxytocinmentioning

confidence: 99%

Neurotransmitters: central and peripheral mechanisms

2000

Int J Impot Res

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Re¯exive erection initiated by recruitment of penile afferents, involves both autonomic and somatic efferents. The re¯ex is mediated at the spinal cord level, modulated by supraspinal in¯uences, and may use several transmitters. Dopamine, acetylcholine, nitric oxide, and peptides, such as oxytocin and ACTHaa-MSH, seem to have a facilitatory role, whereas serotonin may be either facilitatory or inhibitory, and enkephalins are inhibitory. Peripherally, the balance between contractant and relaxant factors controls the degree of contraction of the smooth muscle of the corpora cavernosa, and determines the functional state of the penis. Noradrenaline contracts both corpus cavernosum and penile vessels via stimulation of a 1 -adrenoceptors. The role of endothelins in the control of penile smooth muscle tone is presently unclear. Neurogenic nitric oxide (NO) is considered the most important factor for relaxation of penile vessels and corpus cavernosum. The role of other mediators, released from nerves or endothelium has not been de®nitely established.

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Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat

Cited by 126 publications

References 42 publications

Spinal proerectile effect of apomorphine in the anesthetized rat

Spinal proerectile effect of apomorphine in the anesthetized rat

Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat

Neurotransmitters: central and peripheral mechanisms

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