2000
DOI: 10.1590/s0100-879x2000000600003
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Abstract: Oxytocin (OT), a nonapeptide, was the first hormone to have its biological activities established and chemical structure determined. It was believed that OT is released from hypothalamic nerve terminals of the posterior hypophysis into the circulation where it stimulates uterine contractions during parturition, and milk ejection during lactation. However, equivalent concentrations of OT were found in the male hypophysis, and similar stimuli of OT release were determined for both sexes, suggesting other physiol… Show more

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Cited by 155 publications
(122 citation statements)
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References 47 publications
(122 reference statements)
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“…Oxytocin (OT) is also involved in hydromineral homeostasis and vascular and cardiac relaxation (17)(18)(19)(20)(21)(22)(23). It has long been recognized that OT increases renal electrolyte excretion in various species, and that the natriuretic and kaliuretic effects are AVP independent.…”
Section: Neurohypophyseal Hormones and The Control Of Sodium And Watementioning
confidence: 99%
“…Oxytocin (OT) is also involved in hydromineral homeostasis and vascular and cardiac relaxation (17)(18)(19)(20)(21)(22)(23). It has long been recognized that OT increases renal electrolyte excretion in various species, and that the natriuretic and kaliuretic effects are AVP independent.…”
Section: Neurohypophyseal Hormones and The Control Of Sodium And Watementioning
confidence: 99%
“…In addition, we have demonstrated that in isolated, perfused hearts, an OT antagonist (OTA) blocks basal ANP release (7), suggesting the presence of local OT in the heart. Further study revealed cardiac OT synthesis (8), with OT being detected in the medium of cultured neonatal rat cardiomyocytes (9).…”
mentioning
confidence: 95%
“…The fall in cardiac output in our patients was primarily due to the fall in heart rate, due to the reflex bradycardia associated with phenylephrine administration. Thomas et al studied the effects of phenylephrine and ephedrine on maternal cardiac output using cross-sectional and Doppler echocardiography 17 . Bradycardia secondary to phenylephrine administration was treated with atropine in 11 of 19 patients, and as a result the decreases in cardiac output were comparable to those with ephedrine administration.…”
Section: Discussionmentioning
confidence: 99%
“…Oxytocin receptors are widely present in the cardiovascular system 18 . The activation of oxytocin receptors in the heart releases atrial natriuretic peptide; on the endothelial receptors, it stimulates the release of nitric oxide 17 . As a result, vasodilation is observed.…”
Section: Discussionmentioning
confidence: 99%