Oxytocin has therapeutic effects on cancer, a hypothesis

Imanieh, M H; Bagheri, Fariborz; Alizadeh, Ali Mohammad; Ashkani-Esfahani, Soheil

doi:10.1016/j.ejphar.2014.07.053

Cited by 41 publications

(46 citation statements)

References 152 publications

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“…Childbearing, particularly at a younger age, has been shown consistently to reduce the risk of breast cancer in the long term [12]. Oxytocin is a growth regulator in neoplastic pathology inhibiting proliferation of neoplastic cells of either epithelial (-mammary and endometrial), nervous or bone origin in vitro, as well as mouse and rat mammary carcinomas in vivo [7,8]. On the contrary, in neoplastic cells derived from trophoblast and endothelium, oxytocin was found to promote cell proliferation [7,8].…”

Section: Discussionmentioning

confidence: 94%

“…Oxytocin plays a role also as a growth regulator in neoplastic pathology [7]. In a review, oxytocin was raised as having therapeutic effects on cancer [8]. Further, experimental in vitro studies on human cancer cell lines have shown an inhibitory effect of oxytocin on cancer cell growth [8].…”

Section: Introductionmentioning

confidence: 98%

“…In a review, oxytocin was raised as having therapeutic effects on cancer [8]. Further, experimental in vitro studies on human cancer cell lines have shown an inhibitory effect of oxytocin on cancer cell growth [8]. Lower levels of oxytocin might thus be associated with an increased risk of cancer development.…”

Section: Introductionmentioning

confidence: 99%

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Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden

Jokinen

Mattsson

Lagergren

et al. 2015

Cancer Causes Control

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

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Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden

Jokinen

Mattsson

Lagergren

et al. 2015

Cancer Causes Control

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“…These findings have driven a hypothesis that oxytocin may have therapeutic effects on cancer [28]. Similarly, Misra et al (2012) reported that females with greater parity may reduce their long-term BCa risk because of multiple hormones released during pregnancy that generate genetic changes in the mammary glands which decrease BCa risk in mature breast cells [31].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalent interpretation that greater birth rate protects against female BCa [26] is that the interruption in the normal menstrual cycle during pregnancy and subsequent breast feeding is associated with an interruption in the normal cyclical production of oestrogen [27], but an increase in oxytocin [28]. The public have been extensively educated for decades that oestrogen contributes to BCa as it fuels the growth of most breast cancer tumours [19].…”

Section: Discussionmentioning

confidence: 99%

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

You¹,

Symonds²,

Rühli³

et al. 2018

ABCR

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Purpose: Urbanization, obesity and ageing associated with lifestyle changes (Westernized diet patterns, pollution, physical inactivity) have been proposed as the major contributing factors for the global rise in breast cancer (BCa) and have been the variables used to predict the future breast cancer rate. At the same time, socio-economic level, instead of birth rate, has been proposed for explanation of dramatic regional variations of breast cancer incidence. We sought to determine which factor plays the determining role in predicting worldwide breast cancer incidence rates and regional variations. Methods: Bivariate correlation was conducted to examine the relationships between country-specific estimates of birth rate, BCa incidence, urbanization, overweight, ageing and GDP. Partial correlation was performed to identify the correlation between BCa incidence with each independent variable while we controlled the other four variables. Multiple linear regression was used to identify the most significant predictors of BCa incidence. Post hoc Scheff and independent T-Test analysis were performed to compare mean differences in BCa incidence rates and residuals of BCa standardised on birth rate in the WHO regions, and UN developed and developing regions respectively. Results: Worldwide, BCa incidence rate tends to increase while birth rate decreases and urbanization, overweight, ageing and GDP increase. However, birth rate was the only variable that had a significant correlation with BCa incidence when controlled for the other four variables. Birth rate was the only significant predictor of BCa incidence in regression analysis. Multiple mean differences of BCa incidence between regions were significant, but all disappeared when the contributing effect of birth rate on BCa incidence rate was removed. Conclusions: Birth rate plays a determining role in worldwide BCa incidence rate and regional variations. Current BCa projection methods may estimate future rates of BCa poorly if they fail to incorporate the impact of birth rate.

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Establishment of a nine‐gene prognostic model for predicting overall survival of patients with endometrial carcinoma

Ying

Wang

et al. 2018

Cancer Medicine

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Endometrial carcinoma (EC) is the most common malignant tumor of the female genital tract in developed countries. The prognosis of early stage EC is favorable, but a subset faces high risk of cancer progression or recurrence. EC has a poor prognosis upon progression to advanced or metastatic stages. Therefore, our goal is to build a robust prognostic model for predicting overall survival (OS) in EC patients. In this study, 1571 genes were identified as being associated with OS based on genomewide expression profiles using a training dataset. Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that these genes were involved in various cancer‐related signaling pathways. Nine signature genes were further selected using stepwise selection, and their potential role in the development of EC was demonstrated by performing differential expression analysis between EC and normal uterine tissues. A prognostic model that aggregated these nine signature genes was ultimately established and effectively divided EC patients into two risk groups. OS for patients in the high‐risk group was significantly poorer compared with that of the low‐risk group. This nine‐gene model was subsequently validated and evaluated using the TCGA dataset and shown to have a high discriminating power to distinguish EC patients with an elevated risk of mortality based on the FIGO staging system and other prognostic factors. This study provides a novel prognostic model for the identification of EC patients with elevated risk of mortality and will help to improve our understanding of the underlying mechanisms involved in prognostic EC factors.

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Oxytocin has therapeutic effects on cancer, a hypothesis

Cited by 41 publications

References 152 publications

Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden

Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden

Decreasing Birth Rate Determining Worldwide Incidence and Regional Variation of Female Breast Cancer

Establishment of a nine‐gene prognostic model for predicting overall survival of patients with endometrial carcinoma

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