1993
DOI: 10.1038/365153a0
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Abstract: Pulmonary neuroepithelial bodies, composed of innervated clusters of amine- and peptide-containing cells, are widely distributed throughout the airway mucosa of human and animal lungs. Structurally, neuroepithelial bodies resemble chemoreceptors (such as carotid body, taste buds) and are thought to function as hypoxia sensitive airway sensors. Evidence for this is indirect, however, and the mechanism of oxygen sensing by these cells is unknown. Here we culture neuroepithelial bodies isolated from rabbit fetal … Show more

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Cited by 421 publications
(317 citation statements)
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“…bodies mimicked the reduction in the K + current which is normally seen under hypoxic conditions [2]. In pulmonary arteries H202 induced relaxation via a catalase-sensitive activation of a guanylate cyclase [21].…”
Section: H202 In 02 Actions On Hepatocytesmentioning
confidence: 73%
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“…bodies mimicked the reduction in the K + current which is normally seen under hypoxic conditions [2]. In pulmonary arteries H202 induced relaxation via a catalase-sensitive activation of a guanylate cyclase [21].…”
Section: H202 In 02 Actions On Hepatocytesmentioning
confidence: 73%
“…of absorbance maxima typical for a b-type cytochrome, the presence of several components of the NADPH oxidase complex and the detection of H202 by rhodamine fluorescence suggested that HepG2 cells posses a cyanide-insensitive electron-transfer chain similar to the NADPH oxidase in neutrophils [11] and that they produce H202 depending on the Oz tensions. In pulmonary neuroepithelial bodies histochemically stained with an antibody recognizing the p91 polypeptide of the heme-linked NADPH oxidase, H202 production during 02 sensing was reported [2].…”
Section: H202 In Cytokine Action In Leucocytesmentioning
confidence: 99%
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“…In the CB, hypoxia depolarizes chemoreceptor cells by inhibiting K + channels, leading to the activation of voltage-dependent Ca 2+ channels, Ca 2+ influx and exocytosis. Although this general mechanism seems to be present in all O 2 -sensitive tissues (Youngson, C. et al 1993;Weir, E. K. et a l. 1995), there are inter-species differences in the molecular nature of the K O2 , and even in the same species more than one type of K O2 may be present Pérez-García, M. T. et al 2000a;Patel, A. J. et al 2001;Peers, C et al 2001).…”
Section: Introductionmentioning
confidence: 99%
“…PNEC are chemoreceptors sensitive to hypoxia and hypercapnia and may exert paracrine control on proliferation of adjacent cells (Youngson et al, 1993). They are richly innervated from afferent sensory fibres from the vagus and spinal nerves (Brouns et al, 2003).…”
Section: Introductionmentioning
confidence: 99%