Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

Abstract

Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

“…190 These oxygen-loading nanomaterials can improve wound healing efficiency. Therefore, oxygenproducing biomaterials are essential to cure chronic diabetes wounds in the future [191][192][193][194] (Table 6).…”

“…Lin et al used emulsion technique to prepare NaHS particles (NaHS@MPs), which could be used as in situ depot for continuous release of exogenous H 2 S under physiological conditions. 197 The sustained release of H 2 S from NaHS@MPs promotes several cell behaviors, including epidermal/endothelial cell proliferation and migration, as well as angiogenesis, by extending the activation of cellular ERK1/2 and p38, [181,[192][193][194] Sodium percarbonate PCL nanofibers scaffolds Continuously generating oxygen for up to 10 days [190] Sodium hydrosulfide NaHS@MPs NaHS@MPs sustained release of exogen-ous H2S under physiological conditions [197] Nitric oxide DNICs Continuous release of nitric oxide [201] submit your manuscript | www.dovepress.com…”

Polymeric Materials with Antibacterial Activity: A Review

“…These materials are gaining more attention in the field of bone tissue engineering (BTE) because of their ability to successfully regenerate bone tissue without the need for surgical intervention, thus lowering the invasiveness of the treatment [ 46 ]. Other interesting kinds of materials are those developed by Tamayol et al [ 47 ]. In this work, a system based on poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL) filled with calcium peroxide was developed, thus producing materials with the ability to release oxygen.…”

3D Printing of Metal/Metal Oxide Incorporated Thermoplastic Nanocomposites With Antimicrobial Properties

“…Specifically, they are very attractive for surgical prosthesis since some of the thermoplastics (e.g., PLA, PCL) have been extensively studied for tissue engineering and regenerative medicine application ( Table 1 ). With the integration of M/MO nanoparticles, bacterial infection can be avoided during surgical implantation, which otherwise could affect tissue growth, postpone surgical recovery, upsurge risks of complications, and even cause death ( Abudula et al, 2020 ). For example, Zou et al (2020) prepared nanocomposite scaffolds containing poly(lactic-co-glycolic acid) (PLGA), copper/zinc based zeolitic-imidazolate-frameworks (Cu@ZIP-8) by FDM-based 3D printing for infected bone repair application.…”