Oxygen free radicals and human disease

A single acute hepatotoxic dose of CCl 4 causes oxidative stress in the rat brain

“…GR, therefore plays a central role in maintaining the cellular GSH level. Reduction in GR activity by CCl 4 in the brain, as seen in our results, affects the regeneration of GSH, thus accentuating the effects of GSH depletion [28] . GST plays an important role in protecting cells against ROS mediated injury by detoxification of lipid hydro peroxides formed due to oxidative damage [39] .…”

A single acute hepatotoxic dose of CCl 4 causes oxidative stress in the rat brain

“…GR, therefore plays a central role in maintaining the cellular GSH level. Reduction in GR activity by CCl 4 in the brain, as seen in our results, affects the regeneration of GSH, thus accentuating the effects of GSH depletion [28] . GST plays an important role in protecting cells against ROS mediated injury by detoxification of lipid hydro peroxides formed due to oxidative damage [39] .…”

Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners

“…The increases in superoxide anion concentrations also may be due to the xenobiotic-induced alterations in the activities of the enzymatic and/or non-enzymatic scavenging systems. [48][49][50][51] Preliminary studies in our laboratories have indicated significant differences in the activities of those systems in hepatic and brain tissues in response to those mixtures (results not shown) that may contribute to the observed differences. Thus, a complex set of factors may be involved in the differences in responses by these two tissues.…”

Degradative Action of Reactive Oxygen Species on Hyaluronan

“…The resonances, clearly visible in the case of chondroitin sulfate, were observable in the HA solutions only upon prolonged incubation with hypochlorous acid. The conclusion of the primary action of HOCl on the N-acetyl groups was confirmed also by a study using 13 C NMR spectroscopy, which showed that application of a large excess of hypochlorous acid led to the degradation of carbohydrate rings with formate as the final product. 61 As further methods appropriate for studies of changes occurring during the degradation of hyaluronans by ROS, the following physicochemical and analytical techniques come into consideration: infrared (IR) spectroscopy in both solution and solid states as a non-destructive methodology 62 and matrixassisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry as a destructive methodology.…”

A single acute hepatotoxic dose of CCl 4 causes oxidative stress in the rat brain

“…GR, therefore plays a central role in maintaining the cellular GSH level. Reduction in GR activity by CCl 4 in the brain, as seen in our results, affects the regeneration of GSH, thus accentuating the effects of GSH depletion [28] . GST plays an important role in protecting cells against ROS mediated injury by detoxification of lipid hydro peroxides formed due to oxidative damage [39] .…”

Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners

“…The increases in superoxide anion concentrations also may be due to the xenobiotic-induced alterations in the activities of the enzymatic and/or non-enzymatic scavenging systems. [48][49][50][51] Preliminary studies in our laboratories have indicated significant differences in the activities of those systems in hepatic and brain tissues in response to those mixtures (results not shown) that may contribute to the observed differences. Thus, a complex set of factors may be involved in the differences in responses by these two tissues.…”

Degradative Action of Reactive Oxygen Species on Hyaluronan

“…The resonances, clearly visible in the case of chondroitin sulfate, were observable in the HA solutions only upon prolonged incubation with hypochlorous acid. The conclusion of the primary action of HOCl on the N-acetyl groups was confirmed also by a study using 13 C NMR spectroscopy, which showed that application of a large excess of hypochlorous acid led to the degradation of carbohydrate rings with formate as the final product. 61 As further methods appropriate for studies of changes occurring during the degradation of hyaluronans by ROS, the following physicochemical and analytical techniques come into consideration: infrared (IR) spectroscopy in both solution and solid states as a non-destructive methodology 62 and matrixassisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry as a destructive methodology.…”

A single acute hepatotoxic dose of CCl 4 causes oxidative stress in the rat brain

“…GR, therefore plays a central role in maintaining the cellular GSH level. Reduction in GR activity by CCl 4 in the brain, as seen in our results, affects the regeneration of GSH, thus accentuating the effects of GSH depletion [28] . GST plays an important role in protecting cells against ROS mediated injury by detoxification of lipid hydro peroxides formed due to oxidative damage [39] .…”

Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners

“…The increases in superoxide anion concentrations also may be due to the xenobiotic-induced alterations in the activities of the enzymatic and/or non-enzymatic scavenging systems. [48][49][50][51] Preliminary studies in our laboratories have indicated significant differences in the activities of those systems in hepatic and brain tissues in response to those mixtures (results not shown) that may contribute to the observed differences. Thus, a complex set of factors may be involved in the differences in responses by these two tissues.…”

Degradative Action of Reactive Oxygen Species on Hyaluronan

“…The resonances, clearly visible in the case of chondroitin sulfate, were observable in the HA solutions only upon prolonged incubation with hypochlorous acid. The conclusion of the primary action of HOCl on the N-acetyl groups was confirmed also by a study using 13 C NMR spectroscopy, which showed that application of a large excess of hypochlorous acid led to the degradation of carbohydrate rings with formate as the final product. 61 As further methods appropriate for studies of changes occurring during the degradation of hyaluronans by ROS, the following physicochemical and analytical techniques come into consideration: infrared (IR) spectroscopy in both solution and solid states as a non-destructive methodology 62 and matrixassisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry as a destructive methodology.…”