2006
DOI: 10.1016/j.febslet.2006.06.037
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Abstract: Unraveling of microbial genome data has indicated that two distantly related truncated hemoglobins (trHbs), HbN and HbO, might occur in many species of slow-growing pathogenic mycobacteria. Involvement of HbN in bacterial defense against NO toxicity and nitrosative stress has been proposed. A gene, encoding a putative HbN homolog with conserved features of typical trHbs, has been identified within the genome sequence of fast-growing mycobacterium, Mycobacterium smegmatis. Sequence analysis of M. smegmatis HbN … Show more

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Cited by 37 publications
(38 citation statements)
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“…In contrast, the genomic organization of glbN is not very well conserved across mycobacterial species. It is quite possible that trHbN may have distinct roles in different mycobacterial species, as has recently been shown for the function of trHbN of M. smegmatis and M. tuberculosis (27); thus, the conservation of the glbN gene organization among different species of mycobacteria may not be very relevant.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast, the genomic organization of glbN is not very well conserved across mycobacterial species. It is quite possible that trHbN may have distinct roles in different mycobacterial species, as has recently been shown for the function of trHbN of M. smegmatis and M. tuberculosis (27); thus, the conservation of the glbN gene organization among different species of mycobacteria may not be very relevant.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies in our laboratory (27,42) and the laboratory of Ouellet et al (40,41) have indicated that trHbN of M. tuberculosis has a potent ability to detoxify nitric oxide (NO) and relieves the toxicity of NO and nitrosative stress (42) in Escherichia coli and Mycobacterium smegmatis. The high rate of NO oxidation catalyzed by oxygenated trHbN suggests that this may be one of the vital defense systems in M. tuberculosis (41,42) for coping with the toxic effects of NO and nitrosative stress that may be important for allowing the intracellular survival of the bacterium in macrophages.…”
mentioning
confidence: 99%
“…M. smegmatis provided an excellent model system to understand the functional relevance of these two proteins due to the fact that it lacks the combination of LprI-HbN and is more sensitive to lysozyme than M. tuberculosis. Additionally, HbN produced by M. smegmatis is not functional as an NO scavenger and lacks posttranslational modifications identified in the HbN of M. tuberculosis (10). HbN is glycosylated at its C terminus via its association with mannosyl residues that possibly facilitate phagocytosis of M. tuberculosis (11).…”
Section: Discussionmentioning
confidence: 99%
“…The inactivation of the glbN gene of M. bovis BCG impaired the ability of stationary-phase cells of the organism to protect aerobic respiration from NO (24). Dikshit and colleagues (14,25) and Ouellet et al (24) showed that trHbN of M. tuberculosis has a potent ability to relieve the toxicity of NO and nitrosative stress in Escherichia coli and M. smegmatis. The aerobic organism M. tuberculosis can use trHbO to collect and deliver available O 2 to the components of the electron transport chain in order to survive in the granulomas (16,26).…”
mentioning
confidence: 99%