Oxo-centered trinuclear ruthenium acetates: Structure and applications

Water‐Soluble μ‐oxo triruthenium Compound of Biological Interest: H‐Bonds Network and Interaction with HSA

“…It has been formulated either as [Ru 3 O(CH 3 COO) 6 (CH 3 OH) 3 ] + or [Ru 3 O(CH 3 COO) 6 (H 2 O) 3 ] + , taking into account the synthetic conditions (in ethanol, followed by successive resuspensions in methanol) and the species' affinity for water. [7,28] The use of the hydrated salts RuCl 3 and NaCH 3 COO and non-dry solvents contributes to product formulation uncertainty regarding the identity of the coordinated solvent.…”

“…Apparently, there is consensus that a seventh acetate ion is present in the composition of this species, either as a counter ion or by occupying one of the ruthenium coordination positions in a monodentate fashion. [7,28,29] The synthetic route uses a significant excess of acetate anions from sodium acetate and glacial acetic acid (Scheme 1), leading to an inherent difficulty in getting 1 a without any contamination with acetate ions. The actual counter-ion of 1 a was not worth attention since most of the other [Ru 3 O(CH 3 COO) 6 (L) 3 ] + compounds are isolated as salts of PF 6 À , ClO 4 À , and others.…”

“…They do not necessarily act in primary tumors, having diverse behaviors such as interfering in cell mobility and cancer metastasis. [7] Other dimensions of cancer cell development are being targeted, such as cell cycle arrest, induction of cancer cells apoptosis, evasion of immune regulation, and augmented angiogenesis. [68][69][70][71] 4-aminopyridine itself has been proven to act diversely.…”

“…The actual counter-ion of 1 a was not worth attention since most of the other [Ru 3 O(CH 3 COO) 6 (L) 3 ] + compounds are isolated as salts of PF 6 À , ClO 4 À , and others. [7,28] However, two literature precedents address the presence of the chloride anion as a persistent species in the composition of the crude product of synthesis. [30,31] Our objective was to synthesize the water-soluble compound 1.…”

“…[5,6] The present work also deals with the analysis of the μ-oxo trinuclear ruthenium complexes of general formula [Ru 3 O-(CH 3 COO) 6 (L) 3 ] n (L = solvent, phosphines, N-heterocycles, and others; n = 0, + 1). [7] Interest in their biological applications is relatively recent, and our research group has been at the forefront of this field, publishing studies revealing their in vitro anticancer, trypanocidal, and vasodilator properties. [8][9][10][11][12][13][14] Different approaches were used to achieve these properties, including coordinating functional biomolecules like NO and CO that can be released through photoactivation; [11,13,[15][16][17] coordination of quinolinic ligands; [12,18] and exploring the ortho-metalation of phenazines to introduce a metalo-intercalator within the triruthenium cluster structure.…”