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Cited by 27 publications
(18 citation statements)
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“…One of the very first reports on IDO in human transplantation immunology comes from Holmes et al In their report the authors suggested that the serum abnormalities in oxidative tryptophan metabolism observed in renal allograft recipients during acute rejection, infection and OKT3 therapy reflect a biological response to IFN-release in that patient population [104]. However, as far as the systemic changes in tryptophan and kynurenine due to IDO activation are concerned, the cellular source of excessive IDO production has not been addressed in their study.…”
Section: Ido In Human Transplantation Immunologymentioning
confidence: 97%
“…One of the very first reports on IDO in human transplantation immunology comes from Holmes et al In their report the authors suggested that the serum abnormalities in oxidative tryptophan metabolism observed in renal allograft recipients during acute rejection, infection and OKT3 therapy reflect a biological response to IFN-release in that patient population [104]. However, as far as the systemic changes in tryptophan and kynurenine due to IDO activation are concerned, the cellular source of excessive IDO production has not been addressed in their study.…”
Section: Ido In Human Transplantation Immunologymentioning
confidence: 97%
“…In patients with renal allografts, increased IDO1 activation correlates with episodes of acute rejection and chronic transplant dysfunction compared with controls [311,312]. Elevated IDO1 activity, as determined by the measurement of the Kyn/L-Trp ratio in serum, has accordingly been posited as a non-invasive early marker of eventual transplant rejection as an alternative to biopsies since elevated IDO1 activity can be detected as early as 1 day post-transplantation [311,313]. However, rather than playing a direct role in rejection of the organ transplant, enhanced IDO1 activity in lung allograft recipients is thought to merely represent a marker of the chronic inflammation associated with organ transplantation [314].…”
Section: Transplantation the Ultimate Goal In Organ Transplantationmentioning
confidence: 99%
“…However, clinical studies have not supported the experimental data. Holmes et al suggested that an increase of Kyn plasma level after transplantation was associated with acute kidney graft rejection in human beings [13]. Brandacher et al demonstrated that acute kidney rejection was associated with simultaneously increased serum and urinary Kyn/Trp ratios [14].…”
Section: Introductionmentioning
confidence: 98%