Oxidative stress status in nutritionally stunted children

Aly, Gamal S.; Shaalan, Ashraf; Mattar, May K.; Ahmed, Hanaa H.; Zaki, Moushira Erfan; Abdallah, Hanaa Reyad

doi:10.1016/j.epag.2014.02.003

Cited by 24 publications

(19 citation statements)

References 24 publications

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“…In current study, the observation that stunted underweight children exhibited significantly lower serum Zn level agreed with the reports of Aly et al [80] in which nutritionally stunted Egyptian children showed significantly lower serum Zn levels , and that of Marasinghe et al [81] in severely stunted and severely underweight Sri Lankan children compared to control group. In fact, the role of Zn in growth had been explained through its influence on the GH/IGF-1 system, thus Hamza et al [42] reported that Egyptian children with short stature and Zn deficiency demonstrated significant increases in serum IGF-1, and height SDS after 3 months of Zn supplementation.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of insulin-like growth factor-1, total ghrelin, and insulin resistance in nutritionally stunted Egyptian children

Abdou

El-Boghdady

El-Maksoud

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Stunting represents a worldwide nutritional problem, which has many negative effects on child health and development. This study aimed to investigate the levels of insulin-like growth factor-1(IGF-1), total ghrelin and insulin resistance, as well as certain micronutrients affecting children growth and skeletal maturity in nutritionally stunted Egyptian children. Stunted children were selected to have height for age Z score (HAZ) <-2 standard deviation, whereas, control children were selected to have HAZ >-2. Stunted children were further classified according to weight for age Z score into normal and underweight groups. All stunted children exhibited significantly lower serum levels of IGF-1, Ca, and Mg compared to normal control children. Additionally, both normal weight and underweight groups showed insignificantly higher total ghrelin levels than the control values. Only stunted underweight children showed significantly lower serum Zn levels compared to control children. Meanwhile, no significant differences were observed in serum glucose and insulin levels, pancreatic beta cell function and insulin resistance between different study groups. In conclusion, these findings highlight the importance of early detection of abnormalities in growth hormone / IGF-1 axis and micronutrients levels in hope that appropriate intervention strategies could improve their status to obtain full growth potential in nutritionally stunted Egyptian children.

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Section: Discussionsupporting

confidence: 91%

Evaluation of insulin-like growth factor-1, total ghrelin, and insulin resistance in nutritionally stunted Egyptian children

Abdou

El-Boghdady

El-Maksoud

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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“…According to this model, under low nutrient conditions such as amino acids and glucose starvation, mTOR is inactive and unable to induce MyoD synthesis with the consequent downregulation of miR-133a/b and miR-206. It is also well known that both sarcopenia and malnutrition are related to increased inflammation and oxidative stress [50][51][52][53]. Notably, a downregulation of miR-133b and miR-206 was observed in the muscle of patients with inflammatory myopathy [54].…”

Section: Discussionmentioning

confidence: 95%

Expression Patterns of Muscle-Specific miR-133b and miR-206 Correlate with Nutritional Status and Sarcopenia

et al. 2020

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Sarcopenia and malnutrition are commonly occurring conditions in the elderly that frequently coexist, leading to substantial effects on morbidity/mortality. Evidence established muscle-specific microRNAs (miRNAs) or myomiRs as essential regulators of skeletal muscle processes, from myogenesis to muscle homeostasis. This study aimed to evaluate the association between myomiRs and sarcopenia and explore the potential of nutrition in mediating this association. qPCR was employed to characterize the myomiR-1, -133a/b, -206, -208b, and -499 expression profiles of 109 non-sarcopenic and 109 sarcopenic subjects. In our sample, the proportion malnourished or at-risk subjects was higher in sarcopenia (p < 0.001). Among the detected myomiRs (miR-133a/b and miR-206), lower levels of miR-133b was significantly associated with the presence of sarcopenia (p = 0.006); however, this relationship was not independent from nutritional status in multivariate analysis, suggesting a mediating effect of nutrition on the relationship between miR-133b and sarcopenia. Correlation analyses showed that lower miR-133b levels were associated with poor nutritional status (Mini Nutritional Assessment Long Form (MNA-LF) score, p = 0.005); furthermore, correlations with albumin, ferritin, and iron were found. Similar results were obtained for miR-206. Statistically more significant correlations were observed in subjects with sarcopenia. In conclusion, our findings highlight a nutrient-miR-133b/miR-206 pathway having a potential role in the age-related muscle decline.

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“…Malnutrition is a major health problem common to underdeveloped and developing countries of the world. It is a major cause of death and accounts for fifty percent deaths in children less than five years [1]. Recent reports have shown that 43 percent of children are stunted all over the world due to poverty and inaccessibility to good food.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Properties and Toxicological Assessment of High Nutrient Biscuit Developed from Blends of Some Cereals and Legume

OB¹,

GN²

2015

J Nutr Disorders Ther

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Materials and Methods Materials Soybean, sorghum, maize, wheatflour, sugar, salt, fat, Sodium bicarbonate (baking powder), lecithin and milk were purchased from the main market in Mushin Lagos State Nigeria. Methods Production of biscuit: Biscuits were produced at laboratory scale using the method of Ayo [10] with a slight modification. Determination of nutritional composition: Nutrition composition of the biscuit was determined using established methods. Proximate and mineral composition was determined using the method of AOAC [11]. Vitamin analysis was also carried via high performance liquid chromatography (HPLC) using the method of AOAC [11]. Sensory evaluation: Sensory evaluation was conducted on the developed biscuit at laboratory scale according to the method described [12]. It was compared to readily available commercial biscuit. They were given the reference codes HNB and CB for the developed and

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Oxidative stress status in nutritionally stunted children

Cited by 24 publications

References 24 publications

Evaluation of insulin-like growth factor-1, total ghrelin, and insulin resistance in nutritionally stunted Egyptian children

Evaluation of insulin-like growth factor-1, total ghrelin, and insulin resistance in nutritionally stunted Egyptian children

Expression Patterns of Muscle-Specific miR-133b and miR-206 Correlate with Nutritional Status and Sarcopenia

Nutritional Properties and Toxicological Assessment of High Nutrient Biscuit Developed from Blends of Some Cereals and Legume

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