volume 278, issue 48, P47834-47841 2003
DOI: 10.1074/jbc.m302660200
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Abstract: Oxidative stress generated during ischemia/reperfusion injury has been shown to augment cellular responsiveness. Whereas oxidants are themselves known to induce several intracellular signaling cascades, their effect on signaling pathways initiated by other inflammatory stimuli remains poorly elucidated. Previous work has suggested that oxidants are able to prime alveolar macrophages for increased NF-B translocation in response to treatment with lipopolysaccharide (LPS). Because oxidants are known to stimulate…

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