Oxidative stress indicators in Chinese women with PCOS and correlation with features of metabolic syndrome and dependency on lipid patterns

Wang, Husheng; Ruan, Xiangyan; Li, Yanglu; Cheng, Jiaojiao; Mueck, Alfred O.

doi:10.1007/s00404-019-05305-7

Cited by 31 publications

(31 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The discrepancy observed in the findings of this study compared to other studies might be due to the presence of other antioxidants in counteracting the oxidative stress during MetS. The levels of SOD and total antioxidant activity were lower in PCOS women with MetS as compared to healthy control [48].…”

Section: The Relationship Between Circulating Vitamin C Concentrationcontrasting

confidence: 99%

“…The MetS subjects presented the increases in GGT, glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), total ferric antioxidant power (FRAP), sulfhydryl groups (SH) and thiobarbituric acid reactive substances (TBARS) [43]. By contrasting the oxidative stress indicators and anti-oxidative capacity in healthy controls, the MDA level was higher whereas the levels of SOD and total antioxidant activity were lower in PCOS subjects with MetS [48]. In a randomised controlled trial, MetS patients assigned with a balanced diet and 500 mL/day orange juice over 12 weeks had higher vitamin C intake with a concomitant increase in antioxidant capacity [53].…”

Section: The Potential Mechanism Of Action For Vitamin C In the Managmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong

Chin

2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In vivo studies showed promising effects of vitamin C, but most of the interventions used were in combination with other compounds. The direct effects of vitamin C remain to be elucidated. In humans, the current state of evidence revealed that lower vitamin C intake and circulating concentration were found in MetS subjects. A negative relationship was observed between vitamin C intake / concentration and the risk of MetS. Oral supplementation of vitamin C also improved MetS conditions. It has been postulated that the positive outcomes of vitamin C may be in part mediated through its anti-oxidative and anti-inflammatory properties. These observations suggest the importance of MetS patients to have an adequate intake of vitamin C through food, beverages or supplements in order to maintain its concentration in the systemic circulation and potentially reverse MetS.

show abstract

Section: The Relationship Between Circulating Vitamin C Concentrationcontrasting

confidence: 99%

Section: The Potential Mechanism Of Action For Vitamin C In the Managmentioning

confidence: 99%

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong

Chin

2020

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…We found significantly higher TOS and OSI levels in serum and FF in patients with PCOS than in those without PCOS, whereas the MDA, TAC, and SOD levels did not significantly differ. However, Wang et al 26 reported higher values for MDA along with lower values for SOD and TAC. Others have found that the SOD and TAC levels increase to compensate for OS 27 , 28 .…”

Section: Discussionmentioning

confidence: 96%

“…Although numerous studies have identified OS in patients with PCOS, the experimental findings of specific OS markers are contradictory 9 , 26 – 28 . We found significantly higher TOS and OSI levels in serum and FF in patients with PCOS than in those without PCOS, whereas the MDA, TAC, and SOD levels did not significantly differ.…”

Section: Discussionmentioning

confidence: 99%

“…Serum MDA concentrations (µmol/L) were determined using micro-MDA detection kits (NanJing Jiancheng Bioengineering Institute Co. Ltd., Nanjing, Jiangsu, China) and ultraviolet spectrophotometry (Shanghai Meipuda Instrument Co., Ltd., Shanghai, China) was performed at 532 nm. SOD was determined using SOD kits (NanJing Jiancheng Bioengineering Institute Co. Ltd.) and spectrophotometry at 450 nm 26 . Using Trolox [(±) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] as a standard, the TAC (mmol Trolox Equiv./L) was determined based on the decolourisation of 2,2′-azinobis (3-ethylbenzothiazoline-6-sulphonate) (ABTS).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial

Gong

Luo

Fan

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups (P < 0.05). Significantly more oocytes were fertilised and cleavage stage embryos were produced in the PCOS-T group than in the PCOS-C group (P < 0.05). GH also improved the rates of implantation and clinical pregnancy, but not significantly (P > 0.05). This study showed that GH alleviated the TOS and OSI level in FF and improved GC mitochondrial dysfunction and oocyte quality in patients with PCOS. Clinical Trial Registration Number: This project was prospectively registered on the Chinese Clinical Trial Registry on October 20, 2018. (ChiCTR1800019437) (https://www.chictr.org.cn/edit.aspx?pid=28663&htm=4).

show abstract