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Cited by 5 publications
(6 citation statements)
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“…34 Chronic oxidative stress has been found to induce and/or maintain a pro-inflammatory retinal microenvironment, thus affecting the onset and progression of AMD. 33 Hence, the modulatory role of oxidative stress, inflammation, and autophagy must be focused in the prospective study. Briefly, our study indicated that NLRX1 is a potential target for the treatment of AMD.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…34 Chronic oxidative stress has been found to induce and/or maintain a pro-inflammatory retinal microenvironment, thus affecting the onset and progression of AMD. 33 Hence, the modulatory role of oxidative stress, inflammation, and autophagy must be focused in the prospective study. Briefly, our study indicated that NLRX1 is a potential target for the treatment of AMD.…”
Section: Discussionmentioning
confidence: 99%
“…32 Oxidative stress decreased the ability of RPE stem cells and influenced the onset and progression of AMD. 33 In addition, Mitter et al reported that impairment of autophagy promoted the progression of AMD. 34 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) was reported to be a putative therapy targeted against AMD, which was involved in oxidative stress and autophagy.…”
Section: Conflict Of Interestsmentioning
confidence: 99%
“…IL-6 is released from the lymphocytes and macrophages, as well as from the skeletal muscle cells, and acts both as a pro-inflammatory cytokine and as an anti-inflammatory myokine, depending on the stimuli ( 40 ). IL-6 might be one of the key molecules in the RPE response to oxidative stress ( 41 ). A recently study reported that IL-6 was higher in AMD patients than in cataract patients, who all also had AIDS ( 42 ).…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress particularly obstructs the functionality of RPE stem cells by inhibiting mitochondrial activity [ 35 , 37 , 38 , 39 ], thereby creating a pro-inflammatory microenvironment unconducive to appropriate retinal development. Indeed, human RPE cells exposed to greater concentrations of oxidative stress demonstrate a dose-dependent reduction in viability [ 40 ]. Compounded with other factors, these oxidative insults result in the formation of drusen, which are foundational to the progression of dry AMD [ 41 ].…”
Section: General Pathogenesis Of Dry Amdmentioning
confidence: 99%