Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation

Percário, Sandro; Barbosa, Aline da Silva; Varela, Everton Luiz Pompeu; Gomes, Antônio Rafael Quadros; Ferreira, Michelli Erica Souza; Moreira, Thayana de Nazaré Araújo; Dolabela, Maria Fâni

doi:10.1155/2020/2360872

Cited by 70 publications

(36 citation statements)

References 273 publications

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“…In this sense, alternative therapies that elevate GSH and act on oxidative stress are often tested as modifiers of these diseases, such as NAC supplementation [ 148 ]. Thus, a study administering a single intravenous dose of NAC (150 mg/kg) in subjects with Parkinson’s disease revealed an increase in the blood GSH/GSSG and cerebral GSH ratio [ 76 ].…”

Section: Clinical Indicationsmentioning

confidence: 99%

N-Acetylcysteine (NAC): Impacts on Human Health

et al. 2021

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N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon and dependent on the route of administration and high dosages. Its remarkable antioxidant and anti-inflammatory capacity is the biochemical basis used to treat several diseases related to oxidative stress and inflammation. The primary role of NAC as an antioxidant stems from its ability to increase the intracellular concentration of glutathione (GSH), which is the most crucial biothiol responsible for cellular redox imbalance. As an anti-inflammatory compound, NAC can reduce levels of tumor necrosis factor-alpha (TNF-α) and interleukins (IL-6 and IL-1β) by suppressing the activity of nuclear factor kappa B (NF-κB). Despite NAC’s relevant therapeutic potential, in several experimental studies, its effectiveness in clinical trials, addressing different pathological conditions, is still limited. Thus, the purpose of this chapter is to provide an overview of the medicinal effects and applications of NAC to human health based on current therapeutic evidence.

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Section: Clinical Indicationsmentioning

confidence: 99%

N-Acetylcysteine (NAC): Impacts on Human Health

et al. 2021

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“…High ROS concentrations may influence the induction or aggravation of several pathologies ( Figure 1 ), such as hypertension [ 27 ], cardiovascular diseases, diabetes mellitus (DM) and its complications [ 28 ], metabolic syndrome [ 28 , 29 , 30 ], cancer [ 31 ], neurodegenerative diseases [ 32 ], or DNA mutations [ 33 ].…”

Section: Ros and Antioxidantsmentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

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Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

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“…Currently, it is known that 70% of those dopaminergic neurons in CNS die along PD development; however, the symptoms are not noticed due to compensatory mechanisms of the striatum body [ 51 ]. Although the mechanisms responsible for inducing cell death in PD are not completely clarified, it is known that the dopamine metabolism, oxidative stress, mitochondrial dysfunction and neuroinflammation are involved in the death of dopaminergic neurons in CNS [ 4 , 52 ]. Iron (Fe(II)) plays an important role in oxidative changes in PD, being present in several regions of the brain, mainly in dopaminergic neurons of the substantia nigra [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum

Silva

Alves

Martins

et al. 2021

IJMS

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Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed Codium tomentosum, to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells and their anti-inflammatory effects in RAW 264.7 macrophages. Loliolide was obtained from the diethyl ether extract, purified through column chromatography and identified by NMR spectroscopy. The neuroprotective effects were evaluated by the MTT method. Cells´ exposure to 6-OHDA in the presence of Loliolide led to an increase of cells´ viability in 40%, and this effect was mediated by mitochondrial protection, reduction of oxidative stress condition and apoptosis, and inhibition of the NF-kB pathway. Additionally, Loliolide also suppressed nitric oxide production and inhibited the production of TNF-α and IL-6 pro-inflammatory cytokines. The results suggest that Loliolide can inspire the development of new neuroprotective therapeutic agents and thus, more detailed studies should be considered to validate its pharmacological potential.

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Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation

Cited by 70 publications

References 273 publications

N-Acetylcysteine (NAC): Impacts on Human Health

N-Acetylcysteine (NAC): Impacts on Human Health

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum

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