Oxidative Stress in Muscle Diseases: Current and Future Therapy

Serra, Andrey Jorge; Prokić, Marko D.; Vasconsuelo, Andrea Anahi; Pinto, José R.

doi:10.1155/2018/6439138

Cited by 25 publications

(15 citation statements)

References 17 publications

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“…It was reported that aerobic physical exercise is a primary trigger for the formation of free radicals. Increased production of ROS is an indicator of oxidative stress and can cause extensive damage to cells and tissues, leading to cellular dysfunction [ 10 ]. Oxidative stress has been considered a pathological mechanism and contributes to liver injury [ 11 ], while systemic oxidative stress also causes brain damage and kidney failure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Tempe extract reduces cell damage in the liver and kidneys after intensive physical exercise in rats

2020

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Background and Aim: Cells of the liver and kidneys are perpetually exposed to free radicals from endogenous and exogenous sources. High-intensity physical exercise can induce oxidative stress. This study aimed to determine the effects of tempe extract on cell damage in the liver and kidneys of rats after intensive physical exercise. Materials and Methods: This study used five experimental groups: T0 (non-exercised control rats), T1 (rats made to exercise by swimming), and T2-T4 (rats made to exercise by swimming treated with 25, 50, and 100 mg/kg body weight tempe extract). The biochemical parameters that were analyzed included blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN), and creatinine levels. The morphology of liver and kidney tissues was histopathologically and immunohistochemically analyzed. Results: Tempe extract treatment reduced cell damage in the liver and kidney tissues of rats, characterized by decreased expression of caspase-3. In addition, the ALT, AST, ALP, creatinine, and BUN levels of rats were significantly lower in tempe extract-treated rats than in rats after swimming exercise alone. Conclusion: Tempe extract is capable of reducing cell damage and apoptosis in the liver and kidney cells of rats after intensive physical exercise and maintaining biochemical properties similar to the normal physiological state.

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Section: Introductionmentioning

confidence: 99%

Tempe extract reduces cell damage in the liver and kidneys after intensive physical exercise in rats

2020

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“…ingredients (Riezzo, Chiloiro, & Russo, 2005;Serra, Proki c, Vasconsuelo, & Pinto, 2018;Yilmaz & Toledo, 2004).…”

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Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

Clemente

Miguel

Gribner

et al. 2020

Phytotherapy Research

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It is well established that plants from the Brassicaceae family, particularly watercress, have been associated to reduce oxidative DNA damage. Nasturtium officinale R. Br (watercress) contains glucosinolates, with anti-inflammatory action and protective effect on human health against oxidative stress. We aimed to evaluate whether the standardized extract of Nasturtium officinale (SENO) is capable of changing biomarkers of oxidative stress and inflammation in people with physical disabilities. 65 people enrolled this study: as a control group composed by; 15 people with no physical disability assessed once, 25 people with physical disabilities using 750 mg/kg/day of SENO, and 25 people with physical disabilities using 750 mg/kg/day of placebo-control for 5 weeks. Biomarkers of oxidative stress and inflammation were analyzed on day 0 and 36. The results indicated that SENO was associated with decreasing levels of lipid peroxidation, protein carbonyl, catalase, superoxide dismutase, and C-reactive protein. Furthermore, the cytokine kit demonstrated below and out of invertible range, which was impossible to detect the inflammatory process. Despite the cytokine kit was not able to detect the inflammation; these data might provide supportive evidence that SENO, have affected positively people with physical disabilities decreasing their biomarkers of oxidative stress and C-reactive protein. Further studies are required.

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“…Oxidative stress has been proposed as a secondary effect in the Duchenne muscular dystrophy (DMD) (Serra et al, 2018). An alteration of the oxidative balance was detected both in mdx mice and in muscle biopsies or blood from DMD patients.…”

Section: Duchenne Muscular Dystrophymentioning

confidence: 99%

Exercise-Related Oxidative Stress as Mechanism to Fight Physical Dysfunction in Neuromuscular Disorders

et al. 2020

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Neuromuscular diseases (NMDs) are a group of often severely disabling disorders characterized by dysfunction in one of the main constituents of the motor unit, the cardinal anatomic-functional structure behind force and movement production. Irrespective of the different pathogenic mechanisms specifically underlying these disease conditions genetically determined or acquired, and the related molecular pathways involved in doing that, oxidative stress has often been shown to play a relevant role within the chain of events that induce or at least modulate the clinical manifestations of these disorders. Due to such a putative relevance of the imbalance of redox status occurring in contractile machinery and/or its neural drive in NMDs, physical exercise appears as one of the most important conditions able to positively interfere along an ideal axis, going from a deranged metabolic cell homeostasis in motor unit components to the reduced motor performance profile exhibited by the patient in everyday life. If so, it comes out that it would be important to identify a proper training program, suitable for load and type of exercise that is able to improve motor performance in adaptation and response to such a homeostatic imbalance. This review therefore analyzes the role of different exercise trainings on oxidative stress mechanisms, both in healthy and in NMDs, also including preclinical studies, to elucidate at which extent these can be useful to counteract muscle impairment associated to the disease, with the final aim of improving physical functions and quality of life of NMD patients.

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Oxidative Stress in Muscle Diseases: Current and Future Therapy

Cited by 25 publications

References 17 publications

Tempe extract reduces cell damage in the liver and kidneys after intensive physical exercise in rats

Tempe extract reduces cell damage in the liver and kidneys after intensive physical exercise in rats

Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

Exercise-Related Oxidative Stress as Mechanism to Fight Physical Dysfunction in Neuromuscular Disorders

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