Oxidative stress in depressive patients with gastric adenocarcinoma

Abstract

Recent data from several studies suggest that oxidative stress is involved in the biochemical mechanisms that underlie neuropsychiatric disorders. The present study was designed to investigate oxidative stress status in depressive patients with gastric adenocarcinoma (GA) at TNM stage III. Oxidative stress, depression and expression of specific genes were monitored during a pretreatment period. Serum total antioxidant capacity, catalase, superoxide dismutase concentrations, and antisuperoxide anion capacity (A-ASC) were significantly decreased in depressive patients compared to control subjects, whereas serum malondialdehyde (MDA) levels were significantly increased. Importantly, the formation of 8-hydroxy-deoxyguanosine (8-OHdG) accumulated. Furthermore, SYBR Green real-time PCR revealed that the expression levels of human oxoguanine glycosylase 1 and APEX nuclease 1 (APEX1) were increased in depressive patients. Pearson correlation analysis revealed that depression was positively correlated with SAS, SCL-90, MDA, 8-OHdG and APEX1, but negatively correlated with A-ASC. Thus, this study confirms oxidative imbalance in depressive patients with GA, and oxidative stress may play a role in the onset and exacerbation of depression.

Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders

“…In the case of SOD and GPx, there are also some discrepancies between studies. Some of them confirm a link between depression and increased activity of SOD (Wei et al 2009, Sarandol et al 2007). Some researchers confirmed that the occurrence of depression was associated with excessive activity of Gpx (Bilici et al 2001); while others did not detect any difference between the study and control groups (Kotan et al 2011, Kodydkova et al 2009).…”

“…In addition, some inaccuracies may arise from size differences of the studied groups, environmental impacts and the severity of the disease. Furthermore, patients with depression are characterized by decreased activity of glutathione peroxidase (GPx) and increased activity of xanthine oxidase (Ox), an enzyme responsible for the production of hydrogen peroxide and superoxide anion, and superoxide dismutase (SOD) (Maes et al 2011a, Wei et al 2009). In the case of SOD and GPx, there are also some discrepancies between studies.…”

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

“…Elevated MDA levels have also been confirmed in depressed patients suffering from chronic heart failure (Michalakeas et al, 2011) and newly diagnosed gastric adenocarcinoma (Wei et al, 2009). …”

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

“…The power analysis was performed considering the results of a previous study [28] on this subject. We calculated a sample size of 20 patients in both the patient group and the control group for α = 0.05 and β = 0.20 with a power of 0.90 in a 2-tailed test.…”