Oxidative stress in anxiety and comorbid disorders

Hovatta, Iiris; Juhila, Juuso; Donner, Jonas

doi:10.1016/j.neures.2010.08.007

Cited by 297 publications

(229 citation statements)

References 175 publications

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“…The relative diminution of endogenous antioxidants increase cellular susceptibility to oxidative damage (Wang et al, 2004;Valerio et al, 2009). Free radicals possess short half-lives and are less concentrated; as such oxidative damage is best assessed by measuring the amount of products and enzymes produced (Hovatta et al, 2010). SOD converts O 2 .-to H 2 O 2 , and then either CAT or GPx converts the H 2 O 2 to oxygen and water.…”

Section: Discussionmentioning

confidence: 99%

Albizia zygia (DC.) Macbr. Hydroethanol Root Extract Exerts Anti-Oedemic and In Vivo Antioxidant Activities in Animal Models

2017

J App Pharma Sci

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Various parts of Albizia zygia (DC.) Macbr. (Family: Leguminosae-Mimosoideae) are used traditionally in the management of arthritis and pain. The present study evaluated the anti-inflammatory and in vivo antioxidant effects of the hydroethanolic root extract of Albizia zygia in animal models. Oedema was induced by the injection of carrageenan (2% suspension) into the right footpads of 7-day old chicks. The footpad thickness was measured hourly for 5 h. Carrageenan was also administered into rat paw subcutaneous tissues, which subsequently induced oxidative stress and inflammation at the injected site. After 5 h the rats were sacrificed and inflamed paw tissues isolated for antioxidant enzyme analysis. The extract (30-300 mg/kg, p.o.) and the positive control, diclofenac (3-30 mg/kg, i.p.), significantly attenuated pedal oedema when given either preemptively or curatively. The extract also augmented the endogenous expression of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) as well as reduced the activity of myeloperoxidase (MPO) and malondialdehyde (MDA) level at the inflamed site. The results suggest that the hydroethanolic extract of Albizia zygia exerts in vivo anti-inflammatory activity after oral administration and also has antioxidant properties which may contribute to its activity.

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Section: Discussionmentioning

confidence: 99%

Albizia zygia (DC.) Macbr. Hydroethanol Root Extract Exerts Anti-Oedemic and In Vivo Antioxidant Activities in Animal Models

2017

J App Pharma Sci

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“…118 Alterations in mitochondrial functionality are associated with increased production of ROS that can induce oxidative stress and lead to redox modulations of macromolecules. 119,120 Alterations to proteins, lipids, and DNA induced by mitochondrial dysfunction were found in postmortem brain samples, [121][122][123][124] as well as in peripheral blood cells, 68,122,125,126 from patients with BD. Changes in mitochondrial function and redox modulation patterns were strongly associated with lipid peroxidation and DNA aberrations, which include changes in methylated and oxidized DNA.…”

Section: Peripheral Alterationsmentioning

confidence: 99%

Biomarkers for bipolar disorder: current insights

Duong¹,

Syed²,

Scola³

2015

CBF

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Abstract:Currently, there exists a lack of definitive diagnostic tools for neuropsychiatric disorders, particularly molecular markers that could help assess the illness and develop more personalized treatments for different disorders. Understanding of the neurobiology and potential novel treatments for bipolar disorder (BD), one of the most complex psychiatric illnesses, remains poor. This review aims to compile the most reproducible findings regarding the molecular, genetic, and structural changes that occur in BD. Neuroimaging studies have indicated alterations in neural circuits, disrupted white matter integrity, alterations in reward activation, and decreased gray matter (GM) volume. Genetic studies have identified variations in a number of genes that confer risk for BD development. Studies involving peripheral biomarkers include alterations in the levels of oxidative stress, inflammation, and neurotrophins. These potential molecular markers could be used as tools for diagnosis, to assess illness progression, and to help with the improvement of more specific and personalized treatments for patients with BD. Identification of biologically relevant markers could improve the quality of life of patients with BD and revolutionize public health.

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“…Several etiological theories have emerged over the years, including a new theory which involves the role of oxidative stress in the etiology of both anxiety and depressive disorders (109). Oxidative stress refers to the imbalance between antioxidants and oxidant homeostasis.…”

Section: Metals Oxidative Stress and Mental Healthmentioning

confidence: 99%

“…This imbalance can occur when there are decreased levels of antioxidants, there is an increased production of oxidants, or when both phenomena occur simultaneously (110). For several reasons, the brain is thought to be particularly sensitive to oxidative stress (109). Some neurotransmitters in the brain can act as reducing agents.…”

Section: Metals Oxidative Stress and Mental Healthmentioning

confidence: 99%

“…Some neurotransmitters in the brain can act as reducing agents. The brain is abundant in ions, such as copper and iron, that catalyze free radical reactions and lipid substrates used in oxidation (109). Additionally, the brain produces a large amount of free radical by-products because it consumes a large proportion of the body's oxygen.…”

Section: Metals Oxidative Stress and Mental Healthmentioning

confidence: 99%

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Pediatric anxiety and/or depression problems : associations with PM10, fly ash, and metal exposure.

Hagemeyer¹

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Oxidative stress in anxiety and comorbid disorders

Cited by 297 publications

References 175 publications

Albizia zygia (DC.) Macbr. Hydroethanol Root Extract Exerts Anti-Oedemic and In Vivo Antioxidant Activities in Animal Models

Albizia zygia (DC.) Macbr. Hydroethanol Root Extract Exerts Anti-Oedemic and In Vivo Antioxidant Activities in Animal Models

Biomarkers for bipolar disorder: current insights

Pediatric anxiety and/or depression problems : associations with PM10, fly ash, and metal exposure.

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