volume 5, issue 7, P515-530 2013
DOI: 10.18632/aging.100569
View full text
Ehtesham Shafique, Wing C. Choy, Yuhong Liu, Jun Feng, Brenda Cordeiro, Arthur Lyra, Mohammed Arafah, Abdulmounem Yassin-Kassab, Arthus V.D. Zanetti, Richard T. Clements, Cesario Bianchi, Laura E. Benjamin, Frank W. Sellke, Md. Ruhul Abid et al.

Abstract: Age-associated decline in cardiovascular function is believed to occur from the deleterious effects of reactive oxygen species (ROS). However, failure of recent clinical trials using antioxidants in patients with cardiovascular disease, and the recent findings showing paradoxical role for NADPH oxidase-derived ROS in endothelial function challenge this long-held notion against ROS. Here, we examine the effects of endothelium-specific conditional increase in ROS on coronary endothelial function. We have generat…

expand abstract