Oxidative stress but not endothelial dysfunction exists in non‐obese, young group of patients with polycystic ovary syndrome

Abstract

Oxidative stress is prominent while endothelial dysfunction does not exist in young, non-obese patients with PCOS.

Oxidative Stress in Non-Obese Women with Polycystic Ovarian Syndrome

“…This is in agreement with previous reports [15][16][17] which have reported increased oxidative stress even in lean PCOS women. Oxidative stress was previously linked to obesity commonly seen in these women [13,18].…”

“…Oxidative stress was previously linked to obesity commonly seen in these women [13,18]. However, a few other studies have found increase in oxidative stress even in lean PCOS women [15][16][17].…”

“…A few studies have reported increased oxidative stress in obese [13,14] as well as in lean PCOS women [15][16][17]. However, a recent study done in Chinese population reported increased oxidative stress only in obese PCOS women and not in lean PCOS women [18].…”

Evaluation of Oxidative Stress and hsCRP in Polycystic Ovarian Syndrome in a Tertiary Care Hospital

“…Raised SOD might be an over expression of this enzyme as a compensatory adaptive response for the increased demand for dismutation of superoxide radical. Our findings are in accordance with the studies by Sabuncu et al [13], Kuscu et al [29], Azzawie et al [30] and Mohan et al [31] where they reported the presence of oxidative stress in PCOS patients.…”

Oxidative stress versus inflammation, a better predictor of cardiovascular disease risk in polycystic ovary syndrome

“…13 In the present study MDA levels were found to be significantly increased in cases compared to controls (p<0.0001) , this is in agreement with previous research findings which have reported increased oxidative stress in PCOS women irrespective of their BMI. [14][15][16] Oxidative stress was previously linked to obesity commonly seen in these PCOS women. 17,18 Oxidative stress has been implicated in a number of diseases such as cardiovascular disease, neurological disease, malignancies, renal disease, diabetes, inflammatory problems, skin diseases, aging, respiratory diseases, liver diseases and different types of viral infections.…”