Oxidative stress and δ-ALA-D activity in different conditioning regimens in allogeneic bone marrow transplantation patients

Gonçalves, Thissiane L.; Benvegnú, Dalila Moter; Bonfanti, Gabriela; Frediani, Andressa V.; Pereira, Daniela Isabel Brayer; Rocha, João Batista Teixeira da

doi:10.1016/j.clinbiochem.2008.12.001

Cited by 19 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16 d-ALA-D is a sulphhydryl enzyme very sensitive to situations in which oxidative stress plays a role. 11,32,33 In the current study, liver of rats showed marked oxidative stress, which could be linked to d-ALA-D inhibition. In accordance, literature data have demonstrated that the inhibition of d-ALA-D activity can be caused by the oxidation of ÀSH groups located at its active center 45 beside that, the results on hepatic NPSH levels demonstrated that 2-NP exposure causes an increase in NPSH levels that can be considered a compensatory response to the oxidative stress caused by 2-NP.…”

Section: Discussionmentioning

confidence: 91%

Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Ibrahim

Prigol

Hassan

et al. 2010

Cell Biochemistry & Function

View full text Add to dashboard Cite

Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2); 50 mg kg(-1), p.o.) against the 2-nitropropane (2-NP)-induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine). In addition, in view of the association of oxidative stress with 2-NP exposure, hepatic lipid peroxidation, ascorbic acid levels, delta-aminolevulinate dehydratase (delta-ALA-D) and catalase (CAT) activities were evaluated. 2-NP caused an increase of AST, ALT and hepatic lipid peroxidation. 2-NP also caused hepatic histopathological alterations and delta-ALA-D inhibition. (NapSe)(2) (50 mg kg(-1)) prevented 2-NP-induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, delta-ALA-D and lipid peroxidation. Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity.

show abstract

Section: Discussionmentioning

confidence: 91%

Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Ibrahim

Prigol

Hassan

et al. 2010

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Plasma MDA levels were found to be increased after high-dose therapy in these patients (1, 3, 7). In erythrocytes, SOD, glutathione peroxidase and CAT activities were reported to be decreased or increased (1,3,4,7,9). Furthermore, plasma antioxidants such as atocopherol, b-carotene and vitamin C were shown to be depleted (3,(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Conditioning regimens preceding HSCT usually consist of high-dose chemotherapy and/ or TBI. They have severe acute and delayed toxic effects on several tissues, such as mucous membranes, gastrointestinal tract, liver, lung, bladder, central nervous system, and, rarely, other tissues possibly related to peroxidation processes and exhaustion of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Sabuncuoğlu

Kuşkonmaz

Çetinkaya

et al. 2011

Bone Marrow Transplant

View full text Add to dashboard Cite

Conditioning regimens preceding hematopoietic SCT (HSCT) usually consist of high-dose chemotherapy. Chemotherapy and radiation therapy are associated with increased formation of free radicals and depletion of critical plasma and tissue antioxidants. Oxidative stress and antioxidant depletion have been described during the transplantation period in HSCT patients. In a limited number of studies, it was observed that the conditioning regimen resulted in oxidative stress and antioxidant depletion in HSCT patients. The objective of this study was to look for further evidence of oxidative stress and antioxidant status in pediatric HSCT patients. In this study, blood samples were collected from 21 pediatric allo-HSCT patients before and after conditioning therapy. Erythrocyte and plasma malondialdehyde (MDA) levels, erythrocyte reduced and oxidized glutathione (GSH) levels, erythrocyte antioxidant enzymes activities, plasma a-tocopherol and b-carotene levels were determined. After high-dose chemotherapy, erythrocyte and plasma MDA levels increased. Reduced GSH levels decreased whereas oxidized GSH levels increased first and then decreased significantly compared with the values before the chemotherapy regimen. It was also observed that catalase, superoxide dismutase and GSH-S-transferase activities decreased, but there was no change in GSH peroxidase activity. On the other hand, plasma a-tocopherol levels increased, but b-carotene levels did not change.

show abstract

“…HSCT patients were previously shown to be under chronic oxidative stress [1,12]. Oxidative stress was associated with high-dose chemotherapy and/or radiotherapy in subjects undergoing HSCT [13].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Sabuncuoğlu¹,

Öztaş²,

Çetinkaya

et al. 2012

Pharmacology

View full text Add to dashboard Cite

Protein oxidation is defined as the covalent modification of a protein, induced either directly by reactive oxygen species/reactive nitrogen species or indirectly by reaction with secondary by-products of oxidative stress. Protein carbonyls are the most commonly measured products of protein oxidation. Additionally, nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Samples were collected before the preparative regimen (10 days before transplantation; day –10), on transplantation day (day 0), and after transplantation (days 7, 14, and 28) from 16 pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients. The erythrocyte 3-nitrotyrosine expression was shown to be significantly increased after chemotherapy. In accordance, the mean plasma carbonyl levels on days 14 and 28 were significantly higher than on the other days. High-dose chemotherapy applied in the preparative regimen of HSCT may be responsible for this long-term oxidation of plasma proteins. These results show that high-dose chemotherapy resulted in protein oxidation both in plasma and in erythrocytes in HSCT patients.

show abstract

Oxidative stress and δ-ALA-D activity in different conditioning regimens in allogeneic bone marrow transplantation patients

Cited by 19 publications

References 37 publications

Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Evaluation of oxidative and antioxidative parameters in pediatric hematopoietic SCT patients

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Contact Info

Product

Resources

About