2015
DOI: 10.18632/aging.100800
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Abstract: CMP-Neu5Ac hydroxylase (Cmah) disruption caused several abnormalities and diseases including hearing loss in old age. However, underling molecular mechanisms that give rise to age-related hearing loss (AHL) in Cmah-null mouse are still obscure. In this study, Cmah-null mice showed age-related decline of hearing associated with loss of sensory hair cells, spiral ganglion neurons, and/or stria vascularis degeneration in the cochlea. To identify differential gene expression profiles and pathway associated with AH… Show more

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Cited by 39 publications
(48 citation statements)
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References 50 publications
(49 reference statements)
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“…SIRT3 is considered a crucial protein against oxidative stress, since it deacetylates and activates several proteins related to mitochondrial function and antioxidant enzymes (Alhazzazi, Kamarajan, Verdin, & Kapila, ; Oliver, Roca, & Sastre‐Serra, ). In this regard, we observed an increase in ROS levels and ROS production after SIRT3 knockdown, as has been widely described before (Finley & Haigis, ; Finley et al, ; Kong et al, ; Park, Choi, Gurunathan, & Kim, ; Pons, Sastre‐Serra, Oliver, & Roca, ). This increase has been attributed to the hyperacetylation, and thus inactivation, of SIRT3 targets, mainly MnSOD, which is one of the most important antioxidant enzymes of the cell (Ozden et al, ; Vassilopoulos, Parisiadou, Yan, & Gius, ; Zou et al, ).…”
Section: Discussionsupporting
confidence: 87%
“…SIRT3 is considered a crucial protein against oxidative stress, since it deacetylates and activates several proteins related to mitochondrial function and antioxidant enzymes (Alhazzazi, Kamarajan, Verdin, & Kapila, ; Oliver, Roca, & Sastre‐Serra, ). In this regard, we observed an increase in ROS levels and ROS production after SIRT3 knockdown, as has been widely described before (Finley & Haigis, ; Finley et al, ; Kong et al, ; Park, Choi, Gurunathan, & Kim, ; Pons, Sastre‐Serra, Oliver, & Roca, ). This increase has been attributed to the hyperacetylation, and thus inactivation, of SIRT3 targets, mainly MnSOD, which is one of the most important antioxidant enzymes of the cell (Ozden et al, ; Vassilopoulos, Parisiadou, Yan, & Gius, ; Zou et al, ).…”
Section: Discussionsupporting
confidence: 87%
“…SIRT3 is a mitochondrial NAD + ‐dependent histone deacetylase, which plays an important role in energy production, metabolism, apoptosis, and cell signaling during aging (D'Aquila, Rose, Panno, Passarino, & Bellizzi, ; Kwon, Park, Choi, Gurunathan, & Kim, ). For example, SIRT3 inhibits lipid accumulation in Mϕs through deacetylation of isocitrate dehydrogenase 2 (Sheng et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, it has been proven that SIRT3 plays key roles in mitochondrial functions through deacetylation of mitochondrial proteins, such as acetyl‐CoA synthase 2 (AceCS2), glutamate dehydrogenase (GDH), and NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit nine (NDUFA9) (Ahn et al, ). A recent study shows that reduction of SIRT3 expression results in oxidative stress and mitochondrial dysfunction due to ROS production in ARHL mice (Kwon, Park, Choi, Gurunathan, & Kim, ). Moreover, SIRT1 activation by pharmacological agents such as resveratrol, increases mitochondrial biogenesis through SIRT1‐dependent deacetylation of the transcriptional coactivator, PGC‐1α (Desquiret‐Dumas et al, ).…”
Section: Introductionmentioning
confidence: 99%